Mechanisms of immune evasion by renal cell carcinoma: tumor-induced T-lymphocyte apoptosis and NFkappaB suppression. Urology. 59:9–14,2002Ng CS; Novick AC; Tannenbaum CS;.Mechanisms of immune evasion by renal
Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at 'hiding' than others. With an increased understanding of tumor immune surveillance, immunotherapy has emerged as a promising treatment strategy for breast cancer, despite historically ...
Tumors use several different immunosuppressive mechanisms to evade otherwise effective T-cell responses. A growing number of immune evasion mechanisms have been characterized mainly in solid tumors. In hematological malignancies, less is known about how different immune escape mechanisms influence tumor ...
immunocompetent mice are able to initiate tumors equally as well in both types of hosts (i.e. immune competent and incompetent) [4]. The leading explanation of this phenomenon is that the strongly immunogenic neoplastic cells developing in the immunocompetent host were eliminated by the immune sy...
tyrosine phosphatase 2 (SHP2) to further suppress T cell receptor (TCR) signaling transduction [44]. PD-1/PD-L1 pathway contributes to tumor immune escape, which has been identified as a main mechanism of adaptive immune resistance (AIR) to enable tumors resistant to immune response [45,46,...
2. Immune-checkpoint inhibitors (ICIs) Immune-checkpoint inhibitors (ICIs) have revolutionized anti-tumor therapy and have become a first-line therapy for the treatment of various cancers. These monoclonal antibodies function to restore the ability of the immune system to detect tumors by manipulating...
In conclusion, this research endeavors to unveil the molecular mechanisms responsible for the evasion of T-cell attacks by QCCs in GC by creating an immunosuppressive environment, resulting in resistance to immune checkpoint inhibitors. Through in-depth research on this mechanism, we will provide theo...
Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a revolutionary treatment strategy for human cancer patients. However, as the response rate to ICI therapy varies widely among different types of tumours, we are beginning to gai
Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48–61 (2015). Article CAS PubMed PubMed Central Google Scholar Spranger, S. & Gajewski, T. F. Impact of oncogenic pathways on evasion of antitumour immune responses. Nat. Rev. Cancer 18...
TAI cells are capable of expressing immunosuppressive factors, such as IL-10, tumor growth factor beta (TGF-β), and prostaglandin E2 (PGE2) to exhibit their effects on T cell inhibition [9], [10], [11]. These factors play a crucial role in supporting tumor immune evasion by regulating ...