Much of the current research into immune escape from cancer is focused on molecular and cellular biology, an area of biophysics that is easily overlooked. A large number of immune drugs entering the clinic are not effective for all patients. Apart from the molecular ...
2025, Biochemistry and Biophysics Reports Show abstract Membrane palmitoylated protein MPP1 inhibits immune escape by regulating the USP12/ CCL5 axis in urothelial carcinoma 2025, International Immunopharmacology Show abstract New insights into T cell metabolism in liver cancer: from mechanism to therapy...
Solid tumors and their associated tumor microenvironment (TME) consist of tumor cells and stromal components, including extracellular matrix (ECM), basement membrane (BM), vasculature, immune cells, and fibroblasts (Fig.1A). During tumor progression, all components change their physical structures and ...
XBP1s in breast cancer cells has been shown to drive malignant progression by promoting tumor cell sur- vival and metastasis under hypoxic conditions9,10, and previously, we reported that aberrant IRE1α-XBP1 signaling in intratumoral leukocytes facilitated immune escape and metastasis in ovarian ...
subsequent degranulation. Conversely, when inhibitory signals prevail, MTOC polarization is hindered, preventing degranulation [96]. However, tumor cells can evade direct killing and achieve immune escape by remodeling their cytoskeleton and reducing their cell stiffness through decreased contractility of ...
First, low expression of major histocompat- ibility complex (MHC) molecule of cancer cells makes cancer cells escape recognition from the immune sys- tem. Second, cancer cells gain the stress phenotypes and try to survive under hypoxic and highly oxidative stress of the TME in which immune ...
For this reason, an innovative antibody-based therapeutic approach has emerged, whose purpose is usually to awaken the patient’s immune system to fight malignancy. Among the mechanisms developed by tumors to escape the immune surveillance, one that aroused a great interest is the upregulation of ...
specific T cells in “cold” tumors and synergizes with CTLA-4 blockade14. Inhibiting (conformational) LFA-1 activation could thus also enable tumor immune escape. Growth/differentiation factor-15 (GDF-15, also known as macrophage inhibitory cytokine MIC-1)15is a divergent member of the ...
Neoplasia PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1 34325342 Sci Rep Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients 34376749 Am J Transl Res Combined treatment with epigenetic agen...
et al. Neoantigen-directed immune escape in lung cancer evolution. Nature 567, 479–485 (2019). Article CAS PubMed PubMed Central Google Scholar Wang, J. et al. Gene expression distribution deconvolution in single-cell RNA sequencing. Proc. Natl Acad. Sci. USA 115, E6437–E6446 (2018)...