During tumor immunosurveillance, leukocytes play a crucial role in the cellular defense system, working collaboratively with other immune components to recognize and eliminate aberrant cells. Integral to this process is the integrin Lymphocyte Function-Associated Antigen 1 (LFA-1). LFA...
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a type of immune cell found abundantly in the tumor microenvironment, respond to the physical properties of fibrosis by synthesizing injury-associated collagens that facilitate wound closure and "re-epithelialization."
has shown considerable potential against several malignancies. However, the utility of immunotherapy is heavily limited due to the low response rate and various side effects in the clinical setting. Immune escape of tumor cells may be a critical reason for such low response rates. Noncoding RNAs...
Negative regulation of antitumor T-cell-immune responses facilitates tumor-immune escape. Here, we show that deletion of CD147, a type I transmembrane molecule, in T cells, strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8+ T-cell-dependent manner. In mouse tum...
Several different tumor types have recently been shown to express functional Fas ligand (FasL), which may represent an additional mechanism of tumor escape. However, the in vivo significance of these findings in the context of potent adversaries such as activated CTL or NK cells remains to be fu...
肿瘤免疫逃避(Tumor immune escape):有些肿瘤细胞具有逃避免疫机制的作用,可以使免疫细胞辨认不出谁是肿瘤细胞,因此 … ebiology.life.nthu.edu.tw|基于 1 个网页 3. 癌免疫逃脱 但这招数对子宫颈癌的癌细胞起不了多大作用。这个现象,叫「癌免疫逃脱」(Tumor Immune Escape)。
4C). We also determined the expression of immune suppressive genes, and observed an increase in immune escape score and high expressions of CD47, LGALS1 and TGFB1 in low-immune response myeloma (Fig. 4D). These data suggested that these tumors possessed active cell growth and proliferation as...
Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma Article 25 October 2024 Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism Article 07 November 2018 Regulatory T cells promote cancer immune-escape through integrin αvβ...
tumor immune escape T cell exhaustion immunotherapy immune checkpoint blockade Introduction CD8+ T lymphocytes represent a promising therapeutic host immune target against cancer (Schumacher and Schreiber, 2015). CD8+ T cell activation is mainly triggered by TCR recognition of MHC-I-peptide complexes but...