Regulatory T cells and immune escape in HCC: understanding the tumor microenvironment and advancing CAR-T cell therapydoi:10.3389/fimmu.2024.1431211REGULATORY T cellsTUMOR microenvironmentLIVER cancerHEPATOCELLULAR carcinomaIMMUNE systemLiver cancer, which most commonly manifests as h...
2. Taube JM, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37. 3. Sanmamed MF...
Dr. Ho: CAR-T cell therapy uses an antibody as a guide or sensor to locate the immune cells—in this case, T-cells—to the tumors then kill tumors using T-cell signaling. So therefore, CAR-T cells use both antibody specifi...
Presence of TGFβ in the tumor microenvironment is one of the most relevant cancer immune-escape mechanisms. TGFβ is secreted in an inactive form, and its activation within the tumor may depend on different cell types and mechanisms than its production. Here we show in mouse melanoma and brea...
The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and correlate with protection but are relatively impaired in severe disease and are asso
[2]Levine B L, Miskin J, Wonnacott K, et al. Global manufacturing of CAR T cell therapy[J]. Molecular Therapy-Methods & Clinical Development, 2017, 4: 92-101.[3]Gardner R, Wu D, Cherian S, et al. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-...
这可能有助于改善治疗实体瘤的努力,毕竟实体瘤占人类癌症的大多数。相关研究结果于2021年8月30日在线发表在Cell期刊上,论文标题为“The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function”。 论文共同通讯作者、宾夕法尼亚大学佩雷尔曼医学院放射肿瘤学教授Andy...
The immune pressure of prevalent host CD8 T cell responses against HIV results in selection of altered viral sequences and viral immune escape (Leslie et al., 2005; Price et al., 1997, 1998). Influenza virus is also known to gradually escape from CD8 T cells with one study estimating ...
Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma Article 25 October 2024 Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism Article 07 November 2018 Regulatory T cells promote cancer immune-escape through integrin αvβ...
Immune cells such as CD8+ T cells are associated with prolonged survival of cancer patients and increased efficacy of immunotherapy 4. A lack of T cells in tumors can lead to resistance to immunotherapy 5. The success of chimeric antigen rec...