Cancer Cell 重磅综述 | 癌症免疫逃逸的特征(上——伪装)2024年10月10日,威尔康奈尔医学院的Lorenzo Galluzzi团队在Cancer Cell杂志上发表了题为“The hallmarks of cancer immune evasion”的综述论文,系统性地提出了癌症免疫逃逸的"三C"理论...
Recent studies have highlighted the complex interaction between these cell-intrinsic and cell-extrinsic mechanisms. The reciprocal communication between cancer stem cells (CSCs) and infiltrating immune cell populations in the tumour microenvironment is a paradigm for these interactions. In this Perspective,...
Like patients with organ transplants, patients injected with human stem cells may have to take immuno-suppressive drugs for the rest of their lives. ES cells could be genetically modified to escape host immune responses. Alternatively, use of patient-specific iPS-derived cells is a possible ...
Stem cell immune evasion in tumorigenesis Para_01 许多实体恶性肿瘤如结肠癌或卵巢癌源自组织干细胞,在获得致癌驱动突变后发展而成。 这些发生突变的干细胞必须在转化过程中同时发展策略以避免免疫识别,才能成长为肿瘤。 Immune evasion during initial transformation ...
PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function Tongfeng Liu ,Shuwen Cheng &Shan Gao Review Article 26 October 2024|Open Access Metabolic gatekeepers: harnessing tumor-derived metabolites to optimize T cell-based immunotherapy efficacy in ...
Metastatic tumors remain lethal due to primary/acquired resistance to therapy or cancer stem cell (CSC)-mediated repopulation. We show that a fasting-mimicking diet (FMD) activates starvation escape pathways in triple-negative breast cancer (TNBC) cells, which can be identified and targeted by drug...
Gray团队在Cancer Cell发表了“Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer”文章。该研究发现吸烟能够促进肺脏中TRM的活化和累积,并且这些TRM能够促进肿瘤的免疫逃逸和抵抗免疫检查点治疗。 通过流式和质谱流式分析肺脏癌旁组织和已故...
9. Haubner S, Mansilla-Soto J, Nataraj S, Kogel F, Chang Q, de Stanchina E, et al.Cooperative CAR targeting to selectively eliminate AML and minimize escape.Cancer Cell2023;41:1871-91.e6 Med Plants 人才招聘 会议...
(HDAC1) via binding to the promoter region and decreasing K14 and K27 histone H3 acetylation; as a result, it induces not only the stem-like features through epigenetic repression of cell cycle inhibitor CDKN2D and CDKN1B but also the immune resistance and chemoresistance through MCL-1 up...
stem cell, comprising a vector comprising a polynucleotide comprising a nucleic acid sequence of suicide gene, a nucleic acid sequence of immune checkpoint gene and a natural cytotoxicity triggering receptor or a TNF-related apoptosis-inducing ligand, wherein the stem cell is a tumor-targeting cell...