immune escapetumor microenvironmentimmunotherapyimmune systemcancer modelingImmune escape is central to the persistence of most, if not all, solid tumors and poses a critical obstacle to successful cancer (immun
We performed a pan-cancer characterization of GIE prevalence across six immune escape pathways in 6,319 uniformly processed tumor samples. To address the complexity of the HLA-I locus in the germline and in tumors, we developed LILAC, an open-source integrative framework. One in four tumors ...
Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD-1) signaling pathway is an important compo...
The recent identification of IDO-expressing tumor cells has implicated this molecule as a key mediator of the tumor immune escape. Mounting evidence indicates that, within the tumor microenvironment, not only tumor cells but also other infiltrating cells such as dendritic cells, monocytes and others ...
(MHC-I) molecules were downregulated in cancer cells. The findings indicated a reduction in tumor immunogenicity in OS, which can be a potential mechanism of tumor immune escape. Of note, CD24 was identified as a novel “don’t eat me” signal that contributed to the immune evasion of OS...
immune escape. Impaired anti-tumor responses of OSCC patients are caused by the tumor itself, by the presence of functional defects or apoptosis of both circulating and tumor-infiltrating T cells, but also by soluble factors of the tumor microenvironment including soluble factors and the hypoxic ...
Tumor cells undergo a selection process called immunoediting that consists of 3 stages: elimination, equilibrium, and escape. In the first stage, the antitumor immune response eliminates the original tumor cells. The tumor then evolves into a static stage (equilibrium), in which some malignant cells...
et al. Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. Mol Cancer. 2019;18:10 41. Huang Y, Liu N, Liu J, Liu Y, Zhang C, Long S. et al. Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMA...
This may be attrib- uted to the fact that the crosstalk between tumor cells and various cells in the Tumor microenvironment (TME) inhibits immune surveillance mediated by immune cells, inducing tumor immune escape and tumor progression. Therefore, more researches should be done about im- mune ...
Correlate relevant kinetic data to inhibitory effects such as exhaustion, anergy, and other escape phenotypes due to interactions with a constantly evolving tumor and its microenvironment. Sensitively measure live cell function and simultaneously scan the temporal components of an ever-evolving immune re...