3. The immune checkpoint network in B cell malignancy 4. The TME in B cell malignancies 5. Immune evasion mechanisms 6. Therapeutic strategies for re-educating the TME 7. Conclusion Conflict of interest disclosure Acknowledgements ReferencesShow full outline Cited by (103) Figures (3) Tables (...
After long-term exposure to inject exosomes from MKN-45 cells, mice developed an immunosuppressive tumor microenvironment in the lung with increased frequency of effector memory CD4T and MDSC, decreased CD8T cell and NK frequency. This immune suppressive environment promotes gastric cancer lung ...
producing C-X-C motif chemokine ligand 9/10 (CXCL9/10). However, the tumor-mediated suppressive microenvironment modulates DCs and suppresses their ability through a variety of mechanisms that eventually lead to tumor immune escape. A variety of TIME factors have demonstrated to negatively impact D...
Inducing Tumor Suppressive Microenvironments through Genome Edited CD47/ Syngeneic Cell VaccinationCancer microenvironmentCancer immunotherapyTumors can escape from the immune system by overexpressing CD47 and other checkpoint blockades. CD47 is expressed ubiquitously by all cells in the body, posing an ...
讲座预告 | Immune suppressive tumor microenvironment in …… 中山大学医学院 2023-11-07 12:15 发表于广东 主讲人简介 周国影,中山大学附属第七医院博士生导师、副研究员,中山大学“百人计划”海外高层次引进人才。2013年毕业于武汉大学...
Abstract IA4: T cell subsets in the tumor microenvironment These studies have helped define the nature of immune responses in the tumor microenvironment, and provide significant new insights into designing novel immune therapies to target the immune suppressive mechanisms including Treg cells (1-6),....
The tumor microenvironment in pancreatic cancer The stroma in PC consists of cells, such as pancreatic stellate cells (PSCs) and immune cells, acellular components, blood vessels and nerves [60]. The relationship between these cellular and acellular elements is intricate. PSCs are thought to inhib...
impaired immune infiltration, deregulation of immune checkpoints, T-cell exhaustion, and presence of suppressive immune cells (reviewed in ref.171) The presence of Tregs and TAMs are significant contributors to the progression, therapeutic response, and resistance in many cancers, including HNSCC. Whil...
between the tumor and the immune system and the intricate regulatory networks in the tumor microenvironment (TME). To maximize the therapeutic effect, the combination of immunotherapy with other therapeutic approaches has gradually gained attention. Radiotherapy (RT) induces micronuclei in tumor cells to...
respiration and break redox homeostasis, thus causing cancer cell apoptosis and damages2,5,12,13. The first example of H2therapy was using hyperbaric H2to treat cutaneous squamous cell carcinoma, presenting a great tumor-suppressive effect14. In recent years, H2therapy was mainly focused on ...