A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microenvironment. Although cancer cells can be immunogenic, ...
These cells, including macrophages, granulocytes, dendritic cells (DCs), innate lymphoid cells, and innate-like T cells, are pivotal in the tumor microenvironment (TME). Innate immune cells are crucial components of the TME, based on which various immunotherapy strat...
However, as tumor cells combat the immune system, an immunosuppressive microenvironment forms, enabling the enactment of a series of immunological escape mechanisms, including the recruitment of immunosuppressive cells and induction of T cell exhaustion to decrease the antitumor immune response. In ...
Tumor microenvironment (TME) | 肿瘤微环境 目前在做GI的Atlas项目,主要分为三类细胞:epithelial,stromal,immune。 其中epithelial就是cancer cell,然后TME就是stromal和immune。 最出名的TME就是CAF和TAM。 Key stromal cells include cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs) and vas...
The immune microenvironment extensively participates in tumorigenesis as well as progression in osteosarcoma (OS). However, the landscape and dynamics of immune cells in OS are poorly characterized. By analyzing single-cell RNA sequencing (scRNA-seq) data, which characterize the transcription state at ...
The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology. The TME is complex, and understanding it requires simplifying approaches. Here we provide an experimental-mathematical approach to decompose the...
The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular composition and functional charac... Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin and Hsing-Chen Tsai ...
NK cells natural killer cells Tregs regulatory T cells CTLs cytotoxic T lymphocytes FDCs follicular dendritic cells MDSCs myeloid-derived suppressor cells TILs tumor-infiltrating lymphocytes APC antigen presenting cells TME tumor microenvironment ICB Immune checkpoint blockade TCR T cell receptor BCR B ce...
Human tumors consist of both epithelial-like tumor cells and their surrounding cells and extracellular components, such as vasculature, fibroblasts, immune cells, endothelial cells and extracellular matrix (ECM). The surrounding components interact with tumor cells to form a microenvironment that favors ...
Aberrant vascular network is a hallmark of cancer. However, the role of vascular endothelial cells (VECs)-expressing PD-L1 in tumor immune microenvironment and antiangiogenic therapy remains unclear. In this study, we used the specimens of cancer patient