肿瘤微环境tumor microenvironment, 简称TME, 主要由肿瘤细胞,及其周围的免疫和炎症细胞,肿瘤相关的成纤维细胞, 和附近的间质组织, 微血管, 以及各种细胞因子和趋化因子构成,是一个复杂的综合系统,可以分成以免疫细胞为主的免疫微环境和成纤维细胞为主的非免疫微环境。图示如下 可以看到,在肿瘤组织内部存在了一些其他...
一方面,PanIN或PDAC小鼠模型中表达α-平滑肌肌动蛋白的成纤维细胞的基因缺失导致了一种更具侵袭性的表型,这表明成纤维细胞天生具有抑制癌症的功能。同样与间质的肿瘤抑制功能一致的是,与辐照成纤维细胞共培养的胰腺癌细胞比与未辐照成纤维细胞共培养的胰腺细胞具有更高的侵袭性。另一方面,在小鼠肺癌模型和kpc为基础的...
肿瘤微环境(tumor microenvironment,TME)由干细胞和分化的癌细胞、细胞外基质(extracellular matrix,ECM)、间充质干细胞(mesenchymal stem cells,MSCs)、癌相关成纤维细胞(cancer-associated fibroblasts,CAFs)、内皮细胞(endothelial cells,ECs)、免疫细胞以及细胞因子和生长因子等构成[1],与肿瘤的生长、侵袭、转移、新血...
GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer. Zhanwei Zhou, Hui Wu, Ruoxi Yang, Alan Xu, Qingyan Zhang, Jingwen Dong, Chenggen Qian, Minjie Sun. China Pharmaceutical University, Nanjing. China. The high redox level of tumor microenvironment inhibits ...
相信在不久的将来,我们将能够以TME为治疗目标,造福更多的癌症患者。 参考文献: 1.Theevolving tumor microenvironment: From cancer initiation to metastatic outgrowth.Cancer Cell.2023 Mar 13;41(3):374-403 原文标题 : 演变中的肿瘤微环境
(tme), which contains diverse cell populations, signaling factors and structural molecules that interact with tumor cells and support all stages of tumorigenesis. in esophageal cancer, environmental exposures can trigger chronic inflammation, which leads to constitutive activation of pro-inflammatory ...
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January, 2016 The function of tumor microenvironment in cancer progression 微环境 肿瘤 麻省理工大学 Douglas 德克萨斯 加利福尼亚 马萨诸塞州 生物医学摘要:vip国际肝胆胰疾病杂志(英文版)
Phenotype molding of stromal cells in the lung tumor microenvironment 基于单细胞测序的肺癌肿瘤免疫微环境中基质细胞的图谱 背景 癌旁的基质细胞,如巨噬细胞,T细胞和纤维母细胞,组成了肿瘤的微环境。肿瘤微环境是一个极其复杂的细胞生态系统,但是这些基质细胞的异质性,以及基质和肿瘤细胞之间的相互影响都还没有明确...
cancer cells to hijack the host machinery to create a niche, i.e., tumor microenvironment for themselves, and progressively modulate it from anti-tumoral to pro-tumoral responses [3]. Furthermore, a lack of unanimity in defining TME in tumor proximal and distal locations, and unavailability of...