Balkwill FR, Capasso M, Hagemann T: The tumor microenvironment at a glance. J Cell Sci 2012, 125(Pt 23):5591-6.Balkwill FR, Capasso M, Hagemann T. The tumor microenvironment at a glance. J Cell Sci. 2012;125:5591-6.Balkwill FR, Capasso M, Hagemann T. The tumor microenvironment at ...
Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation...
The tumor microenvironment at a glance. J Cell Sci. 2012;125:5591–6. Article CAS PubMed Google Scholar Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018;24:541–50. ...
The tumor microenvironment at a glance. J. Cell Sci. 125, 5591–5596 (2012). CAS PubMed Google Scholar Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960–1964 (2006). CAS PubMed Google Scholar Cou...
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At a Glance Tumor budding is proposed as an additional prognostic factor in the eighth edition of the TNM Classification of Malignant Tumors 2017. As a biomarker of tumor progression, budding is part of the tumor microenvironment and involved in the epithelial-to-mesenchymal transition (EMT). ...
AT/RTs are rhabdoid tumors localized in the central nervous system that are believed to originate from stem cells. They are characterized by a unique genomic stability, with biallelic inactivation of the SMARCB1 tumor suppressor gene as the only known recurrent genetic event. SMARCB1 is a core ...
Balkwill, F. R., Capasso, M. & Hagemann, T. The tumor microenvironment at a glance.J. Cell Sci. Front. Med.12 24 ArticleCASPubMedPubMed CentralGoogle Scholar Suvà, M. L. & Tirosh, I. Single-cell RNA sequencing in cancer: lessons learned and emerging challenges.Mol. Cell75, 7–12...
a Random bone marrow (RBM) aspirates from the iliac crest and imaging-guided samples from focal lesions (FL) were processed using CD138-positive selection. b CD138-positive tumor and CD138-negative tumor microenvironment (TME) samples from intra- or paramedullary components were analyzed using ...