1.Theevolving tumor microenvironment: From cancer initiation to metastatic outgrowth.Cancer Cell.2023 Mar 13;41(3):374-403 原文标题 : 演变中的肿瘤微环境
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We further recognized that the tumor microenvironment(TME), herein defined to be composed of heterogeneous andinteractive populations of cancer cells and cancer stem cellsalong with a multiplicity of recruited stromal cell types—thetransformed parenchyma and the associated stroma—is nowwidely appreciated ...
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DNA methylation profiling has emerged as another method capable of distinguishing gliomas by tumor type and provides complementary molecular information to transcriptional profiles. DNA methylation refers to the covalent addition of a methyl group to the fifth position carbon of a cytosine nucleotide result...
Tarloxotinib has been designed as a pro-drug which is converted in a potent HER2/EGFRex20 mutant inhibitor in the hypoxic microenvironment of the tumor to improve specificity and limit systemic toxicity (Koga et al., 2019). ADC treatment of lung malignancies is a rapidly evolving field (Ricc...
locally activated thermogenic adipocytes in the tumor microenvironment accelerate cancer progression by offering fuel sources and is likely to develop resistance to chemotherapy. Here, we enumerate current knowledge about the significant advances made in the origin and physiological functions of thermogenic fa...
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