The infiltration of M2 in the tumor microenvironment is known to facilitate immunosuppression and tumor-promoting properties. In the present study, we investigated the phagocytic potential of these macrophage subsets in oral squamous cell carcinoma (OSCC) in relation to the expression of CD47, the '...
Recent advances in tumor biology demand detailed analysis of the complex interaction of tumor cells with their adjacent microenvironment (tumor stroma) to understand the various mechanisms involved in tumor growth and metastasis. Mononuclear phagocytes or macrophages, a type of innate immune cells, defen...
作者: Karin,Scharffetter-Kochanek 摘要: Background:Tumor-associated macrophages(TAMs) are a prominent inflammatory cell population remodelling tumor microenvironment(1).Accumulated evidence 会议名称: 2010’全国肿瘤分子标志及应用学术研讨会暨第五届中国中青年肿瘤专家论坛 会议地点: 中国江苏苏州 收藏...
Tumor microenvironment: barrier or opportunity towards effective cancer therapy Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic ... ...
Interplay of Tumor Microenvironment Cell Types with Parenchymal Cells in Pancreatic Cancer Development and Therapeutic Implications 来自 掌桥科研 喜欢 0 阅读量: 34 作者:P Guturu,V Shah,R Urrutia 摘要: The process of "induction," namely, the formation of a tissue by the functional interaction ...
tumor microenvironment (TME) plays a critical role in HNSCC tumorigenesis, promotes the evolution of aggressive tumors and resistance to therapy, and thereby adversely affects the prognosis. A complete understanding of the TME factors, together with the highly complex tumor–stromal interactions, can ...
TJs play an important role in the adhesion of cells and their interaction with each other. Most cancers originate from epithelial cells. Thus, it is of significance to examine the role of TJs in the tumor microenvironment (TME) and how they affect cancer metastasis. In epithelium-derived ...
Tumour-associated macrophages in diffuse large B-cell lymphoma: the prognostic and therapeutic impact in a South African centre with high HIV seroprevalence Diffuse large B-cell lymphoma (DLBCL) is a common malignancy among people living with HIV. Macrophage enrichment of the tumour microenvironment (...
Tumor escape involves pretty complicated elements in which the tumor microenvironment (TME) dominates the major part. As one of the chief members in TME, the role of tumor-associated macrophage (TAM) cannot be overlooked. As a brand-new target, more and more researches are focusing on TAMs an...
As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation ...