The infiltration of M2 in the tumor microenvironment is known to facilitate immunosuppression and tumor-promoting properties. In the present study, we investigated the phagocytic potential of these macrophage subsets in oral squamous cell carcinoma (OSCC) in relation to the expression of CD47, the '...
Tumor escape involves pretty complicated elements in which the tumor microenvironment (TME) dominates the major part. As one of the chief members in TME, the role of tumor-associated macrophage (TAM) cannot be overlooked. As a brand-new target, more and more researches are focusing on TAMs an...
The complex interaction between tumor-associated macrophages (TAMs) and tumor cells through several soluble factors and signaling is essential for colorectal cancer (CRC) progression. However, the molecular mechanism involved remains elusive. In this stu
An area where TGFβ appears important in promoting M2-like macrophages is in thetumor microenvironment. Here, so-calledtumor-associated macrophage(TAM) differentiation is driven by TGFβ, with cells adopting an M2-like phenotype which also produce high levels of TGFβ, and can also display enh...
Tumor microenvironment: barrier or opportunity towards effective cancer therapy Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic ... ...
Cell Communication and Signaling https://doi.org/10.1186/s12964-020-0530-4 (2020) 18:59 REVIEW Open Access Tumor microenvironment complexity and therapeutic implications at a glance Roghayyeh Baghban1,2†, Leila Roshangar3†, Rana Jahanban-Esfahlan2*, Khaled Seidi4,5, Abbas Ebrahimi-Kalan...
Both PD-L1 and GEP are inflammatory biomarkers indicative of a T cell–inflamed tumor microenvironment (TME), whereas TMB and MSI-H are indirect measures of tumor antigenicity generated by somatic tumor mutations. PD-L1和GEP都是T细胞炎症性肿瘤微环境(TME)的炎症标志物,而TMB和MSI-H则是由体细胞肿...
(TCR) found on T-CD8 + cells, they are able to identify tumor-associated antigens expressed on the surface of cancer cells. Tumor progression, invasion, and resistance to therapies are closely related to tumor microenvironment (TME) interactions. Cancer cells can evade antitumor immunity ...
Single-cell RNA sequencing studies have suggested that total mRNA content correlates with tumor phenotypes. Technical and analytical challenges, however, have so far impeded at-scale pan-cancer examination of total mRNA content. Here we present a method to quantify tumor-specific total mRNA expression...
Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth. Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment. Despite attempts to depl