Moreover, the number of ILC2 and ILC3 NCR cells was increased in HDM-challenged obese mice compared to HDM-challenged lean mice, with an increased intracellular expression of IL-13, IL-17A and IL-22. At the mRNA level, IL-33 mRNA was strongly increased in HDM-challenged obese mice as ...
The requirement of IL-7R by the primary ILC subsets defined by lineage studies has not been tested systematically across the mucosal surfaces where most ILC2 and ILC3 are located. It is unknown if microenvironments differentially require IL-7 to support ILC homeostasis, and if so, the identity...
固有淋巴样细胞(innate lymphoid cellsILCs)作为免疫哨兵驻扎在粘膜表面,使其能够监视组织,以帮助应对不适当的免疫反应并维持体内平衡,同时在感染或损伤时快速反应以提供保护。 在过敏原诱导的慢性2型肺炎症过程中,类似报警素的细胞因子(如IL-33、IL-25和胸腺...
作者在芍药汤组粪便发酵24小时后,研究了发酵上清液对MNK-3细胞功能的影响,发现芍药汤发酵上清液导致MNK-3细胞核蛋白AHR表达和IL-22分泌增加。此外,芍药汤在发酵过程中显著改变了肠道菌群的组成,芍药汤显著提高了厚壁菌门、乳酸杆菌科、双歧杆菌、瘤胃球菌和Alistipes的丰度,同时降低了大肠杆菌-志贺氏菌、梭杆菌、普氏菌...
肠ILC3s具有高表达的G蛋白偶联受体血管活性肠肽受体2 (VIPR2),VIP激活显著增加了IL-22的产生和上皮的屏障功能。相反,通过VIPR2的信号缺失导致ILC3s生成IL-22的能力受损,并增加炎症诱导的肠道损伤的易感性。因此,内在细胞节律与食物摄入的循环模式协同作用,驱动IL-22的产生,并通过ILC3s中的VIP–VIPR2途径同步...
Intestinal ILC3s had high expression of the G protein-coupled receptor vasoactive intestinal peptide receptor 2 (VIPR2), and activation by VIP markedly enhanced the production of IL-22 and the barrier function of the epithelium. Conversely, deficiency in signaling through VIPR2 led to impaired ...
该研究首次发现肺组织中TGFβ1诱导的Neuropilin-1(简称Nrp1)是ILC2 的肺组织特异性标记。通过条件性敲除小鼠、细胞过继回输实验、高参数流式和转录组测序等技术,系统揭示了Nrp1通过调控IL-33受体ST2的表达水平调节肺ILC2的活化强度参...
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After intervention with Iloprost, the mRNA expression levels of IL 5, IL 13, GATA3 and ST2 were lower than those in IL 33 group (p < 0.05)Conclusion Iloprost may potentially inhibit the proliferation and activation of innate lymphoid cells 2 in mice with acute allergic inflammation, which ...
NK细胞和ILC1表达NKp46(在B6小鼠中又被称为NK1.1)和T-bet(Tbx21),ILC1在IL-12和IL-18等刺激后会产生IFN-γ,参与抗病毒和胞内病原体。 ILC2表达GATA3,在IL-25、IL-33、胸腺基质淋巴细胞生成素(TSLP)刺激后产生IL-13和IL-5,参与对抗蠕虫感染和过敏。