IL-22IL-22RAKT signalingType 3 innate lymphocytes(ILC3 s) are reported to be involved in lung cancer, possibly by producing interleukin-22(IL-22). However, whether ILC3 s and their secreted IL-22 molecules contribute to the pathogenesis of pancreatic cancer(PC) remains unclear. To this ...
(VIPR2), and activation by VIP markedly enhanced the production of IL-22 and the barrier function of the epithelium. Conversely, deficiency in signaling through VIPR2 led to impaired production of IL-22 by ILC3s and increased susceptibility to inflammation-induced gut injury. Thus, intrinsic ...
a, Circadian clock gene expression in bone marrow ILC2Ps and small intestinal ILC1s and ILC2s. ILC2P n = 4; ILC1 n = 3; ILC2 n = 6. b, PER1–VENUS MFI analysis in bone marrow ILC2Ps and small intestine lamina propria ILC1s and ILC2s. ILC2P n = 6; ILC1 and ILC2 n =...
rodentium-induced colitis in concert with the pronounced upregulation of IL-17 and downregulation of IL-22 as compared to littermate controls. Administration of exogenous IL-22, but not neutralization of endogenous IL-17, protected CD18−/− mice from C. rodentium-induced lethal colitis. ...
Results The results showed that PD significantly restored body weight and colon length in mice with chronic colitis, while also reducing colon inflammatory cell infiltration and the expression of IL-6 and IL-1尾. Additionally, PD notably promoted the expression of MUC2, ZO-1, Occludin, and IL-...
Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because of the crucial role of the IL-23/IL-17 axis in the pathogenesis of psoriasis, and it has recently been reported to be involved in ILC3 cell differentiation. In this study, we report that...
transcription factors (TFs), T-box expressed in T cells (T-bet; Tbx21) and RAR-related orphan nuclear receptor γt (RORγt; Rorc), as key regulators of ILC biology. Since then, other canonical TFs have been shown to have a role in the development and function of ILC subsets. In ...
These ex-ILC3s lose expression of RORγt and IL-22 and instead upregulate T-bet, Aiolos, and IFNγ, and may contribute to driving gut inflammation18, 20. Despite these advances, we lack a mechanistic understanding of the factors provoking alterations of ILC3s in the inflamed human gut, ...
ILC3 cells promote the proliferation and invasion of pancreatic cancer cells through IL-22/AKT signalingAKT signalingIL-22IL-22RILC3Pancreatic cancerOur data demonstrated that ILC3s may promote PC pathogenesis through IL-22/IL-22R-AKT signaling, suggesting a potential intervention target for PC ...
TL1A has been shown to promote GM-CSF and IL-22 expression from ILC3s in synergy with IL-1β and IL-23, which contributes to the immune defensive function of CX3CR1+ mononuclear phagocytes in intestinal infection23. Whether ILC3s participate in TL1A-mediated intestinal inflammation is ...