IL-13 signaling via IL-13Rc2 triggers TGF-IM-dependent allograft fibrosis [ J ]. Transplant Res, 2013, 2(1 ): 16.Brunner SM, Schiechl G, Kesselring R, et al. IL-13 sig- naling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis[J]. Transplant Res, 2013, 2:16....
Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signaling 维生素D受体和STAT6互作组调控食道上皮屏障对IL13信号的反应 期刊:Gut (IF=24.5) 引言: 过去几十年来,全球过敏性疾病发病...
The role of IL-13 signaling via its receptor subunits (IL-13Rα1/IL-4Rα and IL-13Rα2) in airway epithelial repair and restoration of intact barrier function is not well understood and was investigated in this study using in vitro models. The blocking of IL-13 signaling via IL-13R...
association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and ...
IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.根据您的关注的重组小鼠白介素IL-13(白细胞介素13),重组小鼠白细胞介素13,重组白细胞介素13,重组白介素IL-13...
IL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis 我们迫切需要更好地理解调节食管上皮重塑的生物学过程,并确定治疗嗜酸性食管炎的新靶点。Marella等人试图定义IL -13...
[2] Gour,N.and M.Wills-Karp,IL-4 and IL-13 signaling in allergic airway disease.Cytokine, 2015.75(1):68-78. [3]Martinez,F.D.and D.Vercelli,Asthma.Lancet,2013. 382(9901):1360-72. [4] Murdoch,J.R.and C.M.Lloyd,Chronic inflammation and asthma. Mutat Res, 2010.690(1-2):24-39...
[2]McCormick, S. M. et al. Commentary: IL-4 and IL-13 receptor* and signaling. 2015. Cytokine 75(1): 38-50. [3]Okragly A, et al. Comparison of the Affinity and in vitro Activity of Lebrikizumab, Tralokinumab...
IL-4和IL-13不仅参与免疫功能,还参与妊娠、胎儿发育、乳腺发育和哺乳,以及大脑功能,包括记忆和学习。更广为人知的是IL-4和IL-13在过敏、哮喘、肺纤维化和tumor发病机制中的作用。 McCormick, S. M. et al. (2015). "Commentary: IL-4 and IL-13 receptor* and signaling." Cytokine 75(1): 38-50. ...
Commentary: IL-4 and IL-13 receptors and signaling. Cytokine, 2015. 2. Junttila. Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes. Frontiers in immunology, 2018. 3. Le Floc'h, A., et al. Dual blockade of IL-4 and IL-13 with dupilumab, ...