and type 2 immunity in pancreatic cancer. Cancer Cell, 2022. 40(2): p. 153-167.e11.8. Dixit, A., A. Sarver, J. Zettervall, H. Huang, K. Zheng, R.A. Brekken, et al., Targeting TNF-alpha-producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling....
IL-33已被确定为一种“警报蛋白”(alarm protein),它在细胞坏死时释放,并与组织感染和创伤密切相关。 近日,宁夏医科大学总医院医学研究所科研团队在Communications Biology发表了题为Interleukin-33 promotes intrauterine adhesion formation in mice through the mitogen-activated protein kinase signaling pathway的研究论文...
2022年12月3日，在头颈肿瘤的PD-1/L1靶向治疗研究领域，南京大学医学院附属口腔医院丁亮副研究员、泥艳红教授和王志勇教授合作团队在国际肿瘤学期刊British Journal of Cancer（影响因子: 9.075，中科院一区）上在线发表题为“IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune esc...
A20 is a master switch of IL-33 signaling in macrophages and determines IL-33-induced lung immunity IL-33主要驱动2型免疫应答,但一些研究表明它也能驱动1型免疫应答。Holgado等人试图确定抗炎蛋白A20在调节巨噬细胞中IL-3...
“IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma”的研究论文。该研究发现了一类具有较高临床响应率的口腔鳞癌(OSCC)亚型,从基因层面揭示了患者PD-1/L1治疗应答的差异,并提出了依据...
2022年12月3日,在头颈肿瘤的PD-1/L1靶向治疗研究领域,南京大学医学院附属口腔医院丁亮副研究员、泥艳红教授和王志勇教授合作团队在国际肿瘤学期刊British Journal of Cancer(影响因子: 9.075,中科院一区)上在线发表题为“IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape ...
2022年12月3日,在头颈肿瘤的PD-1/L1靶向治疗研究领域,南京大学医学院附属口腔医院丁亮副研究员、泥艳红教授和王志勇教授合作团队在国际肿瘤学期刊British Journal of Cancer(影响因子: 9.075,中科院一区)上在线发表题为“IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape ...
The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling. IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines ...
8. Dixit, A., A. Sarver, J. Zettervall, H. Huang, K. Zheng, R.A. Brekken, et al., Targeting TNF-alpha-producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling.JCI Insight, 2022...
Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type...