近日由希望之城国家医疗中心Jianhua Yu研究组《Trends in Immunology》杂志上发表了名为“Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy”的综述文章。IL-15是一种多效细胞因子,可促进NK和CD8+ T细胞的存活、增殖和细胞毒性。这些细胞发挥肿瘤杀伤作用,因此IL-15通路为增强癌症细胞免...
However, the mechanism of this phenomenon is unclear, as IL-15 signaling in skeletal muscle has been virtually unexplored. It has been previously suggested that loss of IL-15Rα in the global KO mouse directly results in an increase in muscle IL-15 secretion, and this increase in secreted ...
3. Ma, S., et al., PDGF-D-PDGFRbeta signaling enhances IL-15-mediated human natural killer cell survival.Proc Natl Acad Sci U S A, 2022. 119(3). 4. Carson, W.E., et al., Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the ...
1. https://ir.immunitybio.com/news-releases/news-release-details/immunitybio-announces-fda-approval-anktivar-first-class-il-15?field_nir_news_date_value[min]= 2.Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical ...
3. Ma, S., et al., PDGF-D-PDGFRbeta signaling enhances IL-15-mediated human natural killer cell survival.Proc Natl Acad Sci U S A, 2022. 119(3). 4. Carson, W.E., et al., Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the ...
对相关文献有感兴趣的伙伴可以在后台直接私信获取哦! 参考文献:Richmond J M , Strassner J P , Lucio Z , et al. Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo[J]. Science Translational Medicine, 2018, 10(450)...
1. Ma, S., M.A. Caligiuri, and J. Yu, Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.Trends Immunol, 2022. 43(10): p. 833-847. 2. Wang, Y., et al., The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK...
2.Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050. 3.Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promising candidate for tumor immunotherapy[J]....
[1] Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050. [2] Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promising candidate for tumor immunotherapy...
1.Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050. 2.Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promi...