近日由希望之城国家医疗中心Jianhua Yu研究组《Trends in Immunology》杂志上发表了名为“Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy”的综述文章。IL-15是一种多效细胞因子,可促进NK和CD8+ T细胞的存活、增殖和细胞毒性。这些细胞发挥肿瘤杀伤作用,因此IL-15通路为增强癌症细胞免...
综上,该研究揭示了IL-15-XBP1s–PIM-2轴调控NK细胞存活和效应功能的新机制,为基于NK细胞的免疫治疗提供了新思路和新靶点。 参考文献 1. Ma, S., M.A. Caligiuri, and J. Yu, Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.Trends Immunol, 2022. 43(10): p. 833-847...
2.Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050.3.Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promising candidate for tumor immunotherapy[J]. C...
综上,该研究揭示了IL-15-XBP1s–PIM-2轴调控NK细胞存活和效应功能的新机制,为基于NK细胞的免疫治疗提供了新思路和新靶点。 参考文献 1. Ma, S., M.A. Caligiuri, and J. Yu, Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.Trends Immunol, 2022. 43(10): p. 833-847...
1. https://ir.immunitybio.com/news-releases/news-release-details/immunitybio-announces-fda-approval-anktivar-first-class-il-15?field_nir_news_date_value[min]= 2.Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical...
[1] Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050. [2] Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promising candidate for tumor immunotherapy...
[1] Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050. [2] Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promising candidate for tumor immunotherapy...
1.Mishra A, Sullivan L, Caligiuri M A, et al. Molecular pathways: interleukin-15 signaling in health and in cancer.[J]. Clinical Cancer Research, 2014, 20(8): 2044-2050. 2.Jakobisiak M, Golab J, Lasek W, et al. Interleukin 15 as a promi...
A. Molecular pathways: interleukin-15 signaling in health and in cancer. Clin. Cancer Res. 20, 2044–2050 (2014). Article CAS PubMed PubMed Central Google Scholar Colpitts, S. L. et al. Cutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression ...
药物名称:BNZ-1 (PEGylated peptide antagonist that binds to the common gamma chain (γc) signaling receptor for the cytokines interleukin (IL)-2, IL-9, and IL-15) 临床试验: NCT03239392 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemi...