IL-4Rα is a receptor subunit shared byIL-4and IL-13, and the development of IL-4Rα-targeted therapies aims to block IL-4 and IL-13 binding to the receptor. This inhibition effectively disrupts the signaling pathway mediated by IL-4 and IL-13, presenting an innovative mechanism known ...
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10. Li Y, Yuan L, Jiang S, Liu S, Xia L, Shen H, et al. Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis. Int ...
IL-17 signaling pathway The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protectin...
IL-1家族细胞因子通过与受体亚基结合激活细胞内信号通路,如IL-1RI/IL-1R1、IL-18Rα/IL-1R5、IL-1Rrp2/IL-1R6或ST2/IL-1R4,然后募集一个辅助受体来形成活性受体复合物。由IL-1α、IL-1β、IL-18、IL-33、IL-36α、IL-36β或IL-36γ触发的信号级联激活MAPK和NF-κB,导致促炎因子、趋化因子和炎症...
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IL 3 signaling pathway(1)|il|pathway|signalingInterleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific a
In mice, IL-13 was secreted homeostatically by dermal innate lymphoid cells and was independent of microbiota, TSLP or IL-33. In the absence of IL-13 signaling, dermal DC2s were stable in number but remained CD11bhi and showed defective activation in response to allergens, with diminished ...
miR-19a could function as a suppressor of MMP13 and thereby retard the severity of RA. The results showed that miR-19a could regulate the expression of MMP13 in HFLS-RA by mediating the proliferation and invasion of HFLS-RA through IL-17 signaling pathway, thereby participating in the ...