In the present study, we sought mechanistic insights into how central nervous system-infiltrating monocytes program resident microglia to mediate angiogenesis and cerebrovascular repair after an intracerebral hemorrhage. In the penumbrae of human stroke brain lesions, we identified a subpopulation of ...
microgliadendritic cellsexperimental autoimmune encephalomyelitismultiple sclerosismouse modelsMultiple sclerosis (MS) is a complex autoimmune disease of central nervous system (CNS) characterized by the myelin sheath destruction and compromised nerve signal transmission. Understanding molecular mechanisms driving MS...
Yang, Hou, Feng, Li, Wang, Qin, Yang: "Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 426, (2020) (PubMed). Aliases for IL-6 Antibodies interleukin...
Microglia Activation Markers Molecules Secreted by VSMC Multiple Myeloma Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Neuroinflammatory Factors Obesity Plasmacytoid Dendritic Cells Search Cytokine and Growth Factor Products ...
Microglia Activation Markers Molecules Secreted by VSMC Multiple Myeloma Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Neuroinflammatory Factors Obesity Plasmacytoid Dendritic Cells Search Cytokine and Growth Factor Products ...
This is consistent with the finding that SMF promotes the elevation of IL-6 in microglia but inconsistent with the finding that SMF inhibits the reduction of IL-6 levels in LPS-stimulated microglia11. We believe that this difference is related to the fact that animal models and models of ...
提出可以通过IL6/JAK2/STAT3信号通路调控小胶质细胞表型,探索了新的潜在的预防和治疗方法。 参考文献: Jin, Y., et al., Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis. Signal Transduct Target Ther, 2022. 7(1): p. 52....
Couch ACM, Solomon S, Duarte RRR, Marrocu A, Sun Y, Sichlinger L, Matuleviciute R, Polit LD, Hanger B, Brown A, Kordasti S, Srivastava DP, Vernon AC (2023) Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells. Brain Behav Immu...
in vivo IL-6Jose, S., et al. (2014). “Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-alpha levels.” J Neuroinflammation 11: 149 neutralization in vivo IL-6Khmaladze, I., et al. (2014). “Mannan induc...
Neurotoxic effects of triclosan in adolescent mice: Pyruvate kinase M2 dimer regulated signal transducer and activator of transcription 3 phosphorylation mediated microglia activation and neuroinflammation Authors - Ziyun Wei View Article rat IF Int J Biol Macromol Injectable hyaluronate-based hydrogel with ...