11.Oxid Med Cell Longev2020:5146982.8. Li Q, et al.(2021) Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36.Brain Behav Immun94:437-457.9. Traustadottir GA, et al.(2019) The imprinted gene Delta like non-canonical Notch ligand 1 (...
Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the secretion of analgesic substances, culmi...
Microglia Homeostasis Molecules Secreted by VSMC Monocyte Markers Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Natural Killer T (NKT) Cells Neuroinflammatory Factors Plasmacytoid Dendritic Cells Regulatory T Cells (Tregs) ...
结果:We demonstrate that IL-10 defcient mice exhibit signifcantly increased infarct sizes on days 3 and 7 and enlarged brain atrophy and impaired neurological outcome on day 14 following tMCAO. In ischemic brains IL-10 producing immune cells included regulatory T cells, macrophages, and microglia...
Microglia Homeostasis Molecules Secreted by VSMC Monocyte Markers Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Natural Killer T (NKT) Cells Neuroinflammatory Factors Plasmacytoid Dendritic Cells Regulatory T Cells (Tregs) ...
Anandamide enhances IL-10 production in activated microglia by target‑ ing CB2 receptors: roles of ERK1/2, JNK, and NF-κB. Glia. 2010;58:135-47.Correa F, Hernangomez M, Mestre L, Loria F, Spagnolo A, Docagne F, Di Marzo V, Guaza C. Anandamide enhances IL-10 production in ...
4e, f). We did not observe increased microglia numbers in the Il-10-expressing αSyn-seeded mice relative to control αSyn-seeded mice in the spinal cord and the brain (Fig. 4a–h). Fig. 4: Intraspinal vIl-10 expression induces microgliosis but not astrogliosis in spinal cords of α...
Yang S, Gao L, Lu F, Wang B, Gao F, Zhu G, et al. Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death. J Neuroinflammation. 2015;12:33. ...
Given that IL-10 is major homeostatic cytokine and its production becomes deregulated with aging, this may suggest that the capacity of microglia to adequately produce IL-10 may be compromised in ALS. We show that blocking IL-10 increased inflammation and precipitated clinical disease onset, ...
Microglia, the resident macrophages of the brain, encode TLRs which primary role is to protect the tissue integrity. However, deregulated activation of TLRs in microglia may lead to chronic neurodegeneration. This double role of microglial responses is often reported in immune-driven neurologic ...