参考资料: [1]Cameron S. McAlpine et al. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease.Nature(2021). [2]A protective signal between the brain’s supporting cells in Alzheimer’s disease.(来源:Nature)
Nature:AD中星形胶质细胞-小胶质细胞串扰的关键介质——IL-3 但目前,神经胶质细胞对阿尔茨海默病(AD)患者大脑中β-淀粉样蛋白(Aβ)和神经纤维tau蛋白的积累和清除的影响尚不清楚。 最近Swirski和Tanzi团队在《Nature》上发表了题为“Astrocyticinterleukin-3 programs microglia and limits Alzheimer’sdisease”的论文...
中枢神经系统主要由两大类细胞组成,神经元(neurons)和神经胶质细胞(glial cells),其中神经胶质细胞分为星形胶质细胞(astrocytes)、小胶质细胞(microglia)和少突胶质细胞(oligodendrocytes)三类。神经胶质细胞生态系统内的交流对神经元功能发挥和...
近日,来自美国麻省总医院和哈佛医学院的Rudolph E. Tanzi团队和Filip K. Swirski团队合作在Nature上发表了题为Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease的最新研究论文。研究发现,星形胶质细胞来源的IL-3介导的星形胶质细胞—小胶质细胞交流是小胶质细胞编程并改善AD病理和认知功能障碍...
揭示阿尔茨海默症微环境内的不同细胞群体的相互作用【2】，并针对此设计新型靶向药物，可能为改善阿尔茨海默症患者的临床结局提供线索。2021年7月14日，来自美国麻省总医院/哈佛医学院的Filip K. Swirski研究组和Rudolph E. Tanzi研究组在Nature上发表题为Astrocytic interleukin-3 programs microglia and limits Alzheimer...
参考资料: [1]Cameron S. McAlpine et al. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease.Nature(2021). [2]A protective signal between the brain’s supporting cells in Alzheimer’s disease.(来源:Nature)
参考资料: [1] Cameron S. McAlpine et al. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. Nature(2021). [2] A protective signal between the brain’s supporting cells in Alzheimer’s disease. (来源:Nature)
(ii)microglia are responsive to this cytokine,(iii)responsiveness(not so much secretion of IL-3)is increased in patients with AD and model systems of AD,and(iv)presence of IL-3 is necessary to allow microglia to counteract some of the detrimental effects of AD:if IL-3 is missing,AD ...
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke
connective tissue mast cells, astrocytes, microglia, megakaryocytes, eosinophils, T cells, keratinocytes and thymic epithelium. IL-3 exerts its biological activities by binding to a 70 kDa, low affinity, ligand-binding IL-3 R alpha subunit, (6) which then recruits a 120 kDa, common beta -...