第1作者 Sabate-Soler, S 标题 Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.文献引用 Glia; 70(7) pg1267-1288 PubMed Id 35262217 第1作者 Magusali, N 标题 A genetic link between risk for Alzheimer's disease and sev...
34均刺激单核细胞存活、增殖和分化为巨噬细胞以及其他单核细胞谱系例如破骨细胞(osteoclast)、树突细胞和小神经胶质细胞(microglia)。 8.如本文所用,术语“ptp ‑ ζ”具有本领域的一般含义并且是指受体型酪氨酸蛋白磷酸酶zeta。ptp ‑ ζ在本领域中也称为“磷酸粘蛋白(phosphacan)”。这种受体是具有两个细胞 ...
By deleting the core autophagy gene Ulk1 in microglia, we reduce this population in the central nervous system of aged mice. Notably, this population is found dependent on IL-34, rather than CSF1, although both are ligands for CSF1R. When aging mice are exposed to autoimmune neuroinflammation...
第1作者 Sabate-Soler, S 标题Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. 文献引用 Glia; 70(7) pg1267-1288 PubMed Id 35262217 第1作者 Magusali, N 标题A genetic link between risk for Alzheimer's disease and severe COVID-19 outcom...
例如,CSF-1和IL-34均刺激单核细胞存活、增殖和分化为巨噬细胞以及其他单核细胞谱系例如破骨细胞(osteoclast)、树突细胞和小神经胶质细胞(microglia)。 如本文所用,术语“PTP-ζ”具有本领域的一般含义并且是指受体型酪氨酸蛋白磷酸酶zeta。PTP-ζ在本领域中也称为“磷酸粘蛋白(phosphacan)”。这种受体是具有两个...
It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to...
In conclusion, we found SAMHD1 dysfunction induced IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells. This finding could lay the foundation for exploring the role of IL-34-targeting microglia in the pathogenesis of Aicardi-Goutières Syndrome....
However, the phenotype of CSF-1R-deficient mice is more severe than that of the CSF1op/op mice; for example, Langerhans cells and microglia are completely absent in CSF-1R–deficient mice (8, 9). Interleukin 34 (IL-34) has been identified as an alternative ligand for CSF-1R (10). ...
It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to...
标题Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. 文献引用 Glia; 70(7) pg1267-1288 PubMed Id 35262217 第1作者 Magusali, N 标题A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. 文...