IL-34 is a tissue- restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol. 2012; 13:753-60. https://doi.org/1038/ni.2360.Wang Y, Szretter KJ, Vermi W, Gilfillan S, Rossini C, Cella M, Barrow AD, Diamond MS, Colonna M. IL-34 is...
第1作者 Sabate-Soler, S 标题 Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.文献引用 Glia; 70(7) pg1267-1288 PubMed Id 35262217 第1作者 Magusali, N 标题 A genetic link between risk for Alzheimer's disease and sev...
34均刺激单核细胞存活、增殖和分化为巨噬细胞以及其他单核细胞谱系例如破骨细胞(osteoclast)、树突细胞和小神经胶质细胞(microglia)。 8.如本文所用,术语“ptp ‑ ζ”具有本领域的一般含义并且是指受体型酪氨酸蛋白磷酸酶zeta。ptp ‑ ζ在本领域中也称为“磷酸粘蛋白(phosphacan)”。这种受体是具有两个细胞 ...
第1作者 Sabate-Soler, S 标题Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. 文献引用 Glia; 70(7) pg1267-1288 PubMed Id 35262217 第1作者 Magusali, N 标题A genetic link between risk for Alzheimer's disease and severe COVID-19 outcom...
It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to...
例如,CSF-1和IL-34均刺激单核细胞存活、增殖和分化为巨噬细胞以及其他单核细胞谱系例如破骨细胞(osteoclast)、树突细胞和小神经胶质细胞(microglia)。 如本文所用,术语“PTP-ζ”具有本领域的一般含义并且是指受体型酪氨酸蛋白磷酸酶zeta。PTP-ζ在本领域中也称为“磷酸粘蛋白(phosphacan)”。这种受体是具有两个...
IL-34 is primarily produced by keratinocytes and neurons and plays a pivotal role in the differentiation and survival of Langerhans cells and microglia [8]. On the other hand, we have identified that IL-34 is highly expressed in various malignant tumors [7, 9,10,11]. We found that IL-...
In conclusion, we found SAMHD1 dysfunction induced IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells. This finding could lay the foundation for exploring the role of IL-34-targeting microglia in the pathogenesis of Aicardi-Goutières Syndrome....
However, the phenotype of CSF-1R-deficient mice is more severe than that of the CSF1op/op mice; for example, Langerhans cells and microglia are completely absent in CSF-1R–deficient mice (8, 9). Interleukin 34 (IL-34) has been identified as an alternative ligand for CSF-1R (10). ...
It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to...