including type I diabetes, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). However, it has also been shown to have potent antitumoral activity, making it a promising candidate for immunotherapy and as an adjuvant material in CAR-T cell therapy (PMID: 22235123, 26966515, ...
In contrast, IL-7R expression on CD4+ memory T cells is not affected, allowing their IL-7-dependent survival in IL-21-transgenic mice. Although IL-21 decreases IL-7R expression on CD8+ memory T cells, this has no impact on their survival since their maintenance in the T cell pEve-Line...
NK cells are identified by the surface expression of CD56 and absence of the T cell marker CD3. A subset of NK cells express the FcγRIII protein, CD16, that enhances NK cell cytotoxic function by aiding in antibody-dependent cellular cytotoxicity (ADCC). NK cell function is largely ...
It has been previously demonstrated that NK cell functionality is responsive to immunotherapies with IL-21 and interferon alpha (IFNα). For example, ex vivo IL-21 treatment expanded CD16+ NK cells9, antagonized the IL-15-dependent expansion of resting NK cells10, and reverses hypo-...
10、bhatts,parvins,zhangy,etal.anti-cd20-interleukin-21fusokinetargetsmalignantbcellsviadirectapoptosisandnk-cell-dependentcytotoxicity[j].blood.2017;129(16):2246-2256. 11、xum,lium,dux,etal.intratumoraldeliveryofil-21overcomesanti-her2/neuresistancethroughshiftingtumor-associatedmacrophagesfromm2tom1phenotyp...
(Supplementary Fig. 5a). Conversely, using the human CD4 T-cell line CEM-GXR25 that expresses GFP driven by HIV-1 LTR in a Tat-dependent manner25, we confirmed that constitutive inhibition of endogenous miR-29 by lentivirus-encoded antisense ‘miR-29-ZIP’ enhanced infection with CXCR4-...
(1, 3 ‑ 5). Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture (9). IL-21 engagement of the IL‑21 receptor on B cells induces Blimp-1 (which mediates plasma cell differentiation), and is important for memory responses (...
specific TM resulted in defective mitochondrial ATP-dependent IL-21 production in CXCR5+CXCR3negTfh cells [cell subset representing more than 80% of IL-21-producing CD4 TM] and, Perforin and Granzyme-B dual-expression in CTL, neither influencing autophagy nor glycolysis-dependent production of IFN...
Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6-dependent survival... D Loffler,K Brocke-Heidrich,G Pfeifer,... - 《Blood》 被引量: 1343发表: 2007年 Interleukin-21 is a growth and survival factor for ...
The aforementioned results showed that PD-1Ab21 was superior to IL-21 for differentiation of TSCM-like cells (Fig.2a). Next, we compared in detail the dose-dependent effects of PD-1Ab21 and IL-21, which were simultaneously prepared, on the differentiation of TSCM-like cells. The superior...