these data demonstrate that HLA-E-restricted NK cell responses impact SIV control in vivo, as has been found in mouse models for other viral infections33,34,35. The formation of a terminally differentiated NK cell subset (NKG2a/clowCD16+) with robust innate and adaptive antiviral activities, ...
To decipher the impact of the Triplet LNP on the different CD8+T-cell subsets in the TME, we performed CITE-seq on the immune-cell compartment of the tumor. In line with our flow cytometry results, the T-cell compartment increased profoundly in tumors of the Triplet LNP-treated mice compar...
IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-211. J. Immunol. 173, 900–909 (2004). Article CAS PubMed Google Scholar Søndergaard, H. et al. Intratumoral Interleukin-21 Increases Antitumor Immunity,...
, 2011). We think that this discrepancy is due to the early and transient nature of induction of genes by IL-21, whereas the microarray analysis to identify IL-21-responsive genes was conducted at a single time point (4 hours). In this study, we demonstrate that IL-21 stimulation of ...