However, our previous studies showed that IL-21 stimulation of EBV-positive DLBCL cell lines leads to increased proliferation. Here, analysis of a rare clinical sample of EBV-positive DLBCL, in combination with a NOD/SCID mouse xenograft model, confirmed the effect of IL-21 on the proliferation...
GPC3 CAR‑T cell proliferation assay We evaluated the expression of PD-1 from different manu- factured CAR-T cells. Compared to the GPC3 CAR-T cells, we observed an increased level of PD-1 expression on the 21 GPC3 CAR-T cells, 9 GPC3 CAR-T cells and 21 × 9 GPC3 CAR-T ...
c, Effect size of the rs1921622 A allele on brain region volume in female APOE-ε4 carriers with cognitive impairment (n = 38, 86 and 57 G/G, G/A and A/A carriers, respectively; ADNI cohort). Linear regression test, adjusted for age, ICV, magnetic resonance imaging (MRI) ...
such as IL-1 antagonists, has shown promise in improving glycemic control in T2DM patients, but its effect on the prevention of T2DM onset remains uncertain [186]. This raises the question of
inoculation (Supplementary Fig. 3). HIV-1 infection was equivalently suppressed by IL-21 even in the absence of NK, NKT and CD8 T cells (Fig. 1f), indicating that the observed antiviral activity of IL-21 did not depend on these cells but likely a direct effect on HIV-1 permissive CD4...
Differentiation markers of mouse C2C12 and rat L6 myogenic cell lines and the effect of the differentiation medium The differentiation grade of cells in culture is dependent on the composition of the culture medium. Two commonly used myogenic cell lines, mouse C2C12 and... GL Portiér,AAGM Bender...
Figure 5. Effect of shIL1R2 on endometrial tissue invasiveness and dissemination. Endometrial implants were localized using fluorescence stereomicroscopy, then counted and measured in situ. Figure summarizes number (A–D, F, and H) and volume (E, G, and I) of lesions per mouse according the...
While blocking IL-22 has no effect on schistosome pathogenesis, helminth infections that colonize the gastrointestinal tract have not been investigated using these mouse models. 5. Gut microbiota and inflammatory bowel diseases The IBD, Crohn’s disease and ulcerative colitis, are thought to be ...
On the other hand, MEK inhibitors have been reported to suppress the production of TNF-α in LPS-stimulated macrophages [40, 41]. In our study conditions, MEK inhibitors slightly suppressed TNF-α production, but the effect was not significant in vitro or in vivo, and so overall iNOS ...
For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1,2,3,4,5,6,7. Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As...