In this study, we developed a fusion protein (PD-1Ab21) of anti-PD-1 antibody and IL-21 that blocked the interaction of PD-1 on T cells with PD-L1 and simultaneously targeted IL-21 to PD-1+T cells. PD-1Ab21 stimulated the differentiation of activated T cells back to memory stem ...
深入探究后,研究人员发现PD-1Ab21能将IL-21靶向活化的T细胞,而且相较于重组IL-21能更有效地诱导活化的CD8+T细胞分化为TSCM细胞(memory stem T cells)。 TSCM细胞在暴露于抗原后具有强大的增殖潜力、长期存活能力以及产生所有记忆和效...
IL-21 produced in tumors and by T cells in culture with GMF contributes to Th17 development.Irina V. PinchukKatherine T. MorrisRobert A. NofchisseyRachel B. EarleyJengYih WuThomas Y. MaEllen J. Beswick
The eradication of tumors by the immune system depends on the generation of antigen-specific T cells which can migrate to sites of tumor growth and maintain their effector functions despite local tumor-derived T-cell inhibitory factors. Interleukin-21 (IL-21) is an IL-2-related cytokine that ...
IL-21(CY025F0010)Figure5.Recombinant Human IL-21 stimulates proliferation of NK-92 cell 参考文献 [1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells....
IL-21 directly suppresses HIV-1 infection in CD4 T cells Given the critical role of IL-21 in viral immunity and its association with HIV-1 disease control7,8,9,10,11,12, we sought to investigate whether IL-21 contributed to the initial host response to HIV-1. Unlike CD4 T cells from...
Dynamic Long-Range Chromatin Interaction Controls Expression of IL-21 in CD4(+) T Cells 来自 国家科技图书文献中心 喜欢 0 阅读量: 10 作者:Lee,Jong-Joo,Song,Min-Ji,Kim,Hyoung-Pyo,Park,Keunhee,Choi,Yeeun 摘要: IL-21, a pleiotropic cytokine strongly linked with ...
一、IL-21的产生及受体分布 IL-21 :主要由 CD4+T 细胞产生,另外自然杀伤 T 细胞(NKT 细胞) 、辅助性滤泡状 T( Tfh) 细胞和 CD8+T 细胞也可部分分泌,部分淋巴造血细胞也可少量分泌。 IL-21受体(IL-21R):主要分布于脾、胸腺、外周血和淋巴结,并广泛表达于骨髓系和淋巴系细胞群,主要表达于 B 淋巴细胞...
分子名称:IL-21 英文名称:Interleukin-21 中文名称:白细胞介素-21 分子别称:IL21,Za11,Interleukin-21 表达区间及表达系统: Biotinylated Human IL-21, Fc,Avitag (IL1-H82F7) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession #Q9HBE4-1). ...
Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and... L Lu,H Cantor - 《中国免疫学杂志(英文版)》 被引量: 260发表: 2008年 Immune suppression by tumor-specific CD4+ regulatory T-cells...