近年来,过继性免疫细胞治疗(Adoptive Cell Transfer Therapy,ACT)已成为肿瘤免疫疗法的研究热点,主要包括CAR-M、CAR-NK、CAR-T、TCR-T、NK 、LAK、DC、CIK、CTL、TIL等。细胞因子能够调节免疫细胞的增殖与分化、信号转导等,是免疫细胞培养、细胞与基因治疗药物(CGT)开发过程中所必需的试剂。
样本类型Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. 实验时长4.5h实验方法双抗夹心法 规格96T ELISA Kit for Interleukin 21 (IL21) FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES!
Cell culture supernates and other biological fluids- Remove particulates by centrifugation and assay immediately or aliquot and store samples at -20℃or -80℃. Avoid repeated freeze-thaw cycles. Note:The samples shoule be centrifugated dequately and no hemolysis or granule was allowed. ...
In Tfh-B cell co-culture assays from either tonsils or peripheral blood, anti-IL-21 inhibited B cell maturation, as measured by Ig production. Conclusions Together, these data demonstrate elevated IL-21 production in SLE patients and provide evidence for an IL-21 mediated effect on Tfh ...
B Cell Markers Common gamma Chain Receptor Family Cytokines and Receptors in Tfh Cell Differentiation and Function Isolation, Culture, and Identification of Natural Killer Cells Multiple Sclerosis and Myelin Related Molecules Natural Killer T (NKT) Cells ...
B Cell Markers Common gamma Chain Receptor Family Cytokines and Receptors in Tfh Cell Differentiation and Function Isolation, Culture, and Identification of Natural Killer Cells Multiple Sclerosis and Myelin Related Molecules Natural Killer T (NKT) Cells ...
(γc) subunit to bind IL-21. IL-21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. IL-21 mediates apoptosis in B-CLL...
Interleukin 21 (IL-21) has pleiotropic effects on both cellular and humoral immune responses, such as stimulation of lymphocyte proliferation, promotion of CD8+T cell and NK cell cytotoxicity, and differentiation of B cells into plasma cells. ...
Authors - Zongfei Ji View Article human IHC FASEB J IL-21 promoting angiogenesis contributes to the development of psoriasis Authors - Dan Han View Article Cancer Sci Spheroid culture to select theoretical therapeutic drugs in intravascular large B-cell lymphoma Authors - Mika Takai View ArticleProte...
IL-21R产生的信号诱导调节性B细胞(B10细胞)扩增和IL-10分泌,因此人和鼠B10细胞能通过IL-21的交互认知调控T细胞自身免疫[8]。IL-21有促进淋巴细胞增生的功能,增加CD8+T细胞和NK细胞的毒性,并直接抑制树突状细胞的抗原提呈作用[9]。有研...