2I, J), showcasing the synergistic potential of the Triplet LNP and anti-PD1 in non-responsive models. Triplet LNP displays a favorable safety profile Considering the established dose-limiting hepatotoxicity of 4-1BB agonists29,30,31,32, we sought to assess the potential hepatotoxicity of the ...
the IL-21 impact on replication competent virus was likely unrelated to SIV-specific T-cell responses (Supplementary Fig.5d, e). To further understand the effect on the viral reservoir, measures of SIV reservoir
, 2011). We think that this discrepancy is due to the early and transient nature of induction of genes by IL-21, whereas the microarray analysis to identify IL-21-responsive genes was conducted at a single time point (4 hours). In this study, we demonstrate that IL-21 stimulation of ...
In these species, CD40L/CD40 engagement induces naïve B cells to become IL-2 responsive (by up-regulating the expression of the IL-2 receptor) driving them to proliferate and secrete IgM (Johnson et al., 1998). Thus, the presence of both stimuli is required to promote PC differentiation...