[6]Egeberg A, et al. The role of the interleukin-23/Th17 pathway in cardiometabolic comorbidity associated with psoriasis. J Eur Acad Dermatol Venereol. 2020;34(8):1695-1706. [7]Mehta H, et al. Differential Changes...
2024年6月,印第安纳大学Mark H. Kaplan教授团队在《Proceedings of the National Academy of Sciences》上发表了论文“An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS i...
"Patients with SpA who carry risk-associated alleles of genes in the IL-23 pathway expressed the highest levels of genes involved in the differentiation and function of T_H17 and T_H1 cells," explains Lars Rogge, the lead investigator of the study. "The presence of protective alleles was ...
1. 银屑病靶点IL-17A,智翔金泰自免单抗再批临床,bioSeedin柏思荟 2. Tsukazaki H, Kaito T. The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis.International Journal of Molecular Sciences. 2020; 21(17):6401. 3. Uppala, Ranjitha et al. "Autoinflammatory psoriasis"-genetic...
PMID: 32165620.Liu T, Li S, Ying S, Tang S, Ding Y, Li Y, Qiao J, Fang H. The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside. Front Immunol. 2020 Nov 17;11:594735. doi: 10.3389/fimmu.2020.594735. PMID: 33281823; PMCID: PMC7705238 ...
DCs derived from Epha2–/– BM secreted more IL-23 when stimulated with β-glucan (Fig. 5c), while TNFα levels were unaffected (Fig. S10). Next, we examined the transcriptional response of β-glucan stimulated DCs using RNA sequencing. KEGG pathway mapping revealed downregulation of genes ...
作者提到，他们未来的工作将集中在IL-23部分激动剂上，期待这些激动剂可在不增强自身免疫的情况下保护免疫功能。原文链接：https://doi.org/10.1016/j.cell.2021.01.018 参考文献 1. Murray, P.J. (2007). The JAK-STAT signaling pathway: input and output integration.J. Immunol. 178, 2623–2629.2....
Notably, IL-23 activates a similar spectrum of STATs as IL-12: STAT1, STAT3, STAT4, and STAT5 (Parham et al., 2002); however, STAT3 is the main player in the IL-23 signaling pathway, whereas STAT4 is the main player in the IL-12 pathway. Once activated, STAT3 homodimers ...
Atg3, Atg5, Atg7, Atg16L1, Beclin-1, Vps34) involved at diference steps of the autophagy pathway (Figure 1) (106 –113 ). Nevertheless, no matter the autophagy gene deleted, the results were similar between the conditional knockout mice: a reduction in the frequencies of thymocytes as ...
while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORgammat expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells. Dendritic cells and macrophages produce IL-23 in respons...