The IGF-1 signaling pathway. Curr. Pharm. Des. 13, 663e669.Laviola L, Naatalicchio A, Giorgino F (2007) The IGF-1 signaling pathway. Curr Pharm Des 13:663–669Luigi Laviola,Annalisa Natalicchio,Francesco Giorgino.Luigi ...
IGF-1 signaling pathway IGF-1 signaling cascade The signal transduction of IGFs on the growth axis is mainly through the activation of two signal transduction chains: the phosphoinositide-3 kinase (PI3-K) activation pathway and MAPK kinase activation pathway, which transmit mitotic and metabolic sign...
接下来,分别在 24 h 时通过 RT-qPCR 和 ELISA 检查无应力组,应力组和应力+ 10 μg/ml IGF-1 中和抗体组的 IGF-1,col-I 和 col-III 的 mRNA 和蛋白质水平。结果表明,IGF-1 中和抗体降低了 col-I/col-III 的 mRNA...
接下来,分别在24 h时通过RT-qPCR和ELISA检查无应力组,应力组和应力+ 10 μg/ml IGF-1中和抗体组的IGF-1,col-I和col-III的mRNA和蛋白质水平。结果表明,IGF-1中和抗体降低了col-I/col-III的mRNA水平(图3 f、g),但IGF-1没有降低(图3 e)。此外,IGF-1、col-I和col-III蛋白水平被IGF-1中和抗体降低(...
大家好,今天给大家解读一篇题为 Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石...
大家好,今天给大家解读一篇题为 Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石...
Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway. Theranostics. 2024 Feb 17;14(4):1764-1780. doi: 10.7150/thno.89174. PMID: 38389846; PMCID: PMC10879870....
大家好,今天给大家解读一篇题为Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石发...
Insulin-like growth factor 1 (IGF-1) promotes phagocytic activity of mouse BV-2 microglial cells via activating PD K/AKT signaling pathway ZHAI liqian1,CHEN Xiaofen2,LU Sitong1,Y A N G Dan',LI Wanqing2,LI Feidi2,W U Fengjiao"*,SUN Meiqun1* 'Department of Histology and Embryology, ...
[关键词] 二甲双胍;2BS细胞;胰岛素样生长因子1;PI3K/Akt信号通路;细胞衰老 [中图分类号] R730 [文献标识码] A [文章编号] 1673-7210(2020)10(b)-0009-04 [Abstract] Objective To explore the effect of metformin (Met) on cell senescence through IGF-1/PI3K/Akt signaling pathway. Methods 2BS cells...