接下来,分别在24 h时通过RT-qPCR和ELISA检查无应力组,应力组和应力+ 10 μg/ml IGF-1中和抗体组的IGF-1,col-I和col-III的mRNA和蛋白质水平。结果表明,IGF-1中和抗体降低了col-I/col-III的mRNA水平(图3 f、g),但IGF-1没有降低(图3 e)。此外,IGF-1、col-I和col-III蛋白水平被IGF-1中和抗体降低(...
接下来,分别在 24 h 时通过 RT-qPCR 和 ELISA 检查无应力组,应力组和应力+ 10 μg/ml IGF-1 中和抗体组的 IGF-1,col-I 和 col-III 的 mRNA 和蛋白质水平。结果表明,IGF-1 中和抗体降低了 col-I/col-III 的 mRNA...
F IGF1 相关信号广泛富集在增殖的近端肾小管细胞的标记基因中。 见图五 Mrc1巨噬细胞的激活增加了IGF1的表达+。 图五 A 显示实验中髓系细胞中 Igf1 表达的变化以及增殖和受伤的 PT 细胞的点阵图。 B 定量PCR结果显示乙醛酸化处理后小鼠肾脏中Igf1表达的倍数变化。单因素方差分析。*, p < 0.05, ** < ...
IGF1 通过 BMP2⁃Smad1/5 信号通路调控犬上颌窦黏膜干细胞 成骨分化[J]. 口腔疾病防治, 2020, 28(1): 16⁃23. The regulatory mechanisms of IGF1 in the osteogenic differentiation of canine MSMSCs via BMP2⁃Smad1/5 signaling pathway LIAO Chunhui1, LI Mingfei2, YE Jinmei1, PENG Wei2,...
大家好,今天给大家解读一篇题为 Mrcl* macro phage-derived lGFlmitigates crystalne phropathyby promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石发作...
The IGF-I signaling pathway. Current Pharmaceutical Design 2007 13 663-669. (doi:10.2174/ 138161207780249146)Laviola L, Naatalicchio A, Giorgino F (2007) The IGF-1 signaling pathway. Curr Pharm Des 13:663–669Laviola, L.; ...
activity has been shown to regulate downstream JAK/STATs45and to crosstalk with insulin/IGF143. The type II diabetes pathway was also identified as enriched in the EPI; this includes genes encoding insulin and IGF receptors as well as downstream PI3K signalling effectors (Supplementary Data1), ...
大家好,今天给大家解读一篇题为Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石发...
Huang L, Chen W, Tan Z, Huang Y, Gu X, Liu L, Zhang H, Shi Y, Ding J, Zheng C, Guo Z, Yu B. Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway. Theranostics. 2024 Feb 17;14(4):1764-1780. ...
10 Zhao Z, Zhang N, Li A, Zhou B, Chen Y, Chen S, et al. Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7–H4 expression through the MEK/ERK signaling pathway. Cancer...