IGF-1 signaling is essential for differentiation of mesenchymal stem cells for peak bone mass. Bone Res 2013; 1: 186.Crane JL, Zhao L, Frye JS, et al. IGF-1 signaling is essential for differentiation of mesenchymal stem cells for peak bone mass. Bone Res 2013;1:186-94.Crane JL, Zhao...
第一种：IGF-1受体缺失或异常 如果孩子存在IGF-1受体缺失或异常的情况，就意味着IGF-1无法正常和受体结合，从而导致生长发育障碍等相关疾病，这种情况现在还没有很好的治疗手段。第二种：IGF-1敏感性差 敏感性差，意味着孩子骨骺端细胞中分布的IGF-1数量较少，或者与IGF-1的结合能力较弱，通俗的理解就是“IGF-...
Microarray analysis revealed that oxidative stress-associated genes, but also several anti-inflammatory signaling pathways were downregulated under control conditions in IGF-1R +/− mice compared to WT. Collectively, these data indicate that IGF signaling can reduce neuro-inflammation dependent sensitivity...
参考文献:Yan B, Zeng C, Chen Y, Huang M, Yao N, Zhang J, Yan B, Tang J, Wang L, Zhang Z. Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling ...
参考文献:Yan B, Zeng C, Chen Y, Huang M, Yao N, Zhang J, Yan B, Tang J, Wang L, Zhang Z. Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway. Stem Cells Int. 2021 Dec 6;2021:5553676. doi: 10.1155/2021/5553676...
生理性衰老中progerin的累积与IGF-1/Akt信号的削弱之间的关联尚不清楚。2022年7月8日，中国医科大学曹流教授团队在Science Advances在线发表题为Progerin modulates the IGF-1R/Akt signaling involved in aging的研究长文，报道了progerin通过调控IGF-1R/Akt信号通路参与衰老的新机制。本研究发现：progerin能定位到...
Anabolic effects of IGF-1 signaling on the skeleton40IGF-1信号传导对骨骼的合成代谢作用41 “fendo-04-00006”—2013/1/31—20:01—page1—#1REVIEWARTICLEpublished:04February2013doi:10.3389/fendo.2013.00006AnaboliceffectsofIGF-1signalingontheskeletonCandiceG.T.Tahimic,YongmeiWangandDanielD.Bikle*Endocrine...
Insulin/IGF-1 Signaling Pathway Antibody Sampler Kit(1)结合特异性抗原:抗体与其他免疫球蛋白分子区别,就在于抗体能与相应抗原发生特异性结合,在体内导致生理或病理效应;在体外产生各种直接或间接的可见的抗原抗体结合反应。抗体是靠其分子上的特殊的结合部位与抗原结合的。
[关键词]胰岛素样生长因子l(IGF-l); B V-2小胶质细胞；吞噬功能；炎症 [中图分类号]R%5, R364.5, R392. 12, R392-33 [文献标志码]A Insulin-like growth factor 1 (IGF-1) promotes phagocytic activity of mouse BV-2 microglial cells via activating PD K/AKT signaling pathway ZHAI liqian1,...
We have demonstrated that 3-phosphoinositide-dependent protein kinase 1 (PDK1)contributes to signaling by insulin or insulin-like growth fctor-1 (IGF-1) th... Takeda,Akihiko,Kido,... - 《Kobe Journal of the Medical Sciences》 被引量: 3发表: 2008年 The suppression of tumor necrosis factor...