IGF-1 signaling pathway IGF-1 signaling cascade The signal transduction of IGFs on the growth axis is mainly through the activation of two signal transduction chains: the phosphoinositide-3 kinase (PI3-K) activation pathway and MAPK kinase activation pathway, which transmit mitotic and metabolic sign...
Rivas MA, et al. Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/F...
综上所述,IQ在BPH大鼠模型中有效减小了前列腺大小,并在体外有效抑制了AR信号传导和PI3K/AKT/mTOR通路,表明其作为BPH治疗的潜力。 Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway...
IGF-1 via PI3K/Akt/S6K signaling pathway protects DRG neurons with high glucose-induced toxicityhigh glucoseneurotoxicitydorsal root ganglioninsulin-like growth factor-1activating transcription factor 3Hyperglycemia-induced toxicity of neurons contributes to the pathogenesis and progression of diabetic ...
Conclusions Our study is the first to evaluate the impact of SNPs in IGF1 pathway genes on PSA recurrence. A genetic interaction between IGF1 rs2946834 and IGF1R rs2016347 might be a predictor of outcomes following RP. 来源:丁香园
) [摘要] 目的探究心肺复苏对胰岛素样生长因子1(i n s u l i n -l i k e g r o w t h f a c t o r -1,I G F -1 )的表达及其调节大鼠心肌损伤的作用机制㊂方法取30只S p r a g u e -D a w l e y 大鼠,随机平均分为5组,每组6只㊂随机选取1组为s h a m 组,其余4...
通路(Pathway) Protein Tyrosine Kinase CAS号(CAS NO.) 867160-71-2 分子式(Formula) C26H23N5O 分子量(Molecular Weight) 421.51 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 运输和保存方法 -25~-15℃保存,有效期3年 注意事项 1. 为了您的安全和健康,请穿实验服并戴一次性手套操作。
大家好,今天给大家解读一篇题为 Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石...
参考文献:Yan B, Zeng C, Chen Y, Huang M, Yao N, Zhang J, Yan B, Tang J, Wang L, Zhang Z. Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling ...
[Key words] Metformin; 2BS cells; Insulin-like growth factor 1; PI3K/Akt signaling pathway; Cell senescence 伴随着人口数量的增长和生活水平的提高,社会正在迅速老龄化,老龄化也是大多数慢性病的主要危险因素[1-3]。二甲双胍(Metformin,Met)作为治疗2型糖尿病的一线用药,通过增强胰岛素敏感性、诱导糖酵解、...