Insulin-like growth factor-1 (IGF1) pathway plays a critical role in malignant transformation, and epidemiology studies have also shown that single nucleotide polymorphisms (SNPs) in IGF1 pathway genes are associated with prostate cancer risk. However, the clinical significance of these SNPs on pros...
IGF-1 signaling pathway IGF-1 signaling cascade The signal transduction of IGFs on the growth axis is mainly through the activation of two signal transduction chains: the phosphoinositide-3 kinase (PI3-K) activation pathway and MAPK kinase activation pathway, which transmit mitotic and metabolic sign...
综上所述,IQ在BPH大鼠模型中有效减小了前列腺大小,并在体外有效抑制了AR信号传导和PI3K/AKT/mTOR通路,表明其作为BPH治疗的潜力。 Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway Young-Jin Choia,b,c, Meiqi Fand, Nishala Erandi Wedamullaa,b,c,e, ...
Laviola,Natalicchio,Giorgino.The IGF Signaling Pathway. Current Pharmaceutical Design . 2007Laviola L, Natalicchio A, Giorgino F. The IGF1 signaling pathway. Curr Pharm Des 13: 663-669, 2007.Laviola, L., Natalicchio, A.,...
参考文献:Yan B, Zeng C, Chen Y, Huang M, Yao N, Zhang J, Yan B, Tang J, Wang L, Zhang Z. Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling ...
(AR) signaling was analyzed in LNCaP cells. Whether IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also examined. The metabolites in ADLE were identified and quantified, which confirmed that...
[Key words] Metformin; 2BS cells; Insulin-like growth factor 1; PI3K/Akt signaling pathway; Cell senescence 伴随着人口数量的增长和生活水平的提高,社会正在迅速老龄化,老龄化也是大多数慢性病的主要危险因素[1-3]。二甲双胍(Metformin,Met)作为治疗2型糖尿病的一线用药,通过增强胰岛素敏感性、诱导糖酵解、...
[关键词]胰岛素样生长因子l(IGF-l); B V-2小胶质细胞；吞噬功能；炎症 [中图分类号]R%5, R364.5, R392. 12, R392-33 [文献标志码]A Insulin-like growth factor 1 (IGF-1) promotes phagocytic activity of mouse BV-2 microglial cells via activating PD K/AKT signaling pathway ZHAI liqian1,...
(AR) signaling was analyzed in LNCaP cells. Whether IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also examined. The metabolites in ADLE were identified and quantified, which confirmed that ADLE contained abundant IQ (20.88 mg/g). IQ significantly reduced the ...
大家好,今天给大家解读一篇题为 Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石...