Fortes MRS, Li Y, Collis E, Zhang Y, Hawken RJ. The IGF1 pathway genes and their association with age of puberty in cattle. Anim Genet. 2012;44:9–5.Fortes MR, Li Y, Collis E, Zhang Y, Hawken RJ: The IGF1 pathway genes and their association with age of puberty in cattle. ...
Insulin-like growth factor-1 (IGF1) pathway plays a critical role in malignant transformation, and epidemiology studies have also shown that single nucleotide polymorphisms (SNPs) in IGF1 pathway genes are associated with prostate cancer risk. However, the clinical significance of these SNPs on pros...
大家好,今天给大家解读一篇题为 Mrcl* macro phage-derived lGFl mitigates crystalne phropathy by promo ting renal tubule cell prolifer ationvia the AKT/Rb signaling pathway(Mrcl*巨噬细胞衍生的lGFl通过AKT/Rb信号通路促进肾小管细胞增殖,减轻晶体肾病变)肾结石的形成非常普遍,发生率高达14.8%,在初次结石...
为了确定功能研究的候选机制和分子的优先顺序,研究人员将来自中年多能祖细胞的单细胞RNA-SEQ数据输入到Invenuity Pathway Analysis中。上游调节因子分析预测在中年骨髓微环境中IGF2升高,NRG1、IGF1、TGF-β1和EGF降低。使用中年LT-HSC RNA-SEQ数据证实了这些预测。 根据几个观察结果,降低的IGF1进一步被认为是首选:(1...
Huang L, Chen W, Tan Z, Huang Y, Gu X, Liu L, Zhang H, Shi Y, Ding J, Zheng C, Guo Z, Yu B. Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway. Theranostics. 2024 Feb 17;14(4):1764-1780. ...
Amentoflavone reverses epithelial-mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis Authors - Hui-Ying Jian View Article mouse WB Int J Biol Sci Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy...
(Supplementary Data1). IL-6 activity has been shown to regulate downstream JAK/STATs45and to crosstalk with insulin/IGF143. The type II diabetes pathway was also identified as enriched in the EPI; this includes genes encoding insulin and IGF receptors as well as downstream PI3K signalling ...
(IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. More...
Blockade of sonic hedgehog signaling decreases viability and induces apoptosis in retinoblastoma cells: The key role of the PI3K/Akt pathway 发表年份 2017 作者 Song, Z;Du, Y;Tao, Y; 期刊 Oncology Letters 标题 Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic...
Amentoflavone reverses epithelial-mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis Authors - Hui-Ying Jian View Article mouse WB Int J Biol Sci Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy...