The IGF/IGF-1 receptor signaling pathway as a potential target for cancer therapy. Drug Resist Updat 1999;2:3-8.Burtscher I, Christofori G (1999) The IGF/IGF-1 receptor signaling pathway as a potential target for cancer therapy. Drug Resist Updat 2(1):3–8 View Article...
Rivas MA, et al. Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/F...
Attenuation of IGF-I receptor signaling has been shown to be an effective strategy in blocking tumor progression in several types of cancer [35], [36], [37]. Since serum IGF-I levels correlate well with prostate cancer risk, the development of strategies to inhibit the proliferation of prosta...
receptor (IGF1R) abolishes the E2 protection of β-cell survival. By immunoprecipitation experiments, we have demonstrated that ERα and IGF1R combine and interact with each other in the β-cells.In addition, E2 can activate two key factors of IGF1R signaling pathway - ERK and PI3K. We ...
onto KEGG pathway maps41thereby creating a searchable visual representation of expression for each pathway component in each cell lineage (https://shiny.crick.ac.uk/embryo_signalling/). To identify ligand and cognate receptor pairs that might suggest signalling pathways to modulate, we curated a lis...
(1 or 10 mg/kg) to a testosterone propionate-induced BPH rat model, and its effects on the prostate weight were evaluated. The effect of IQ on androgen receptor (AR) signaling was analyzed in LNCaP cells. Whether ...
上调差异性表达基因聚类于 Cell adhesion molecules (CAMs )、Circadian en- Irainment、ECM-receptor interactionRegulation of actin cytoskeleton、Mucin type ()-Glycan biosynthesis Mineral absorption、Arrhythmogenic right ventricular cardiomyopathy (ARVO Staphylococcus aureus infection、Rapl 信号通路、Oxytocin ...
Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade....
[关键词]胰岛素样生长因子l(IGF-l); B V-2小胶质细胞;吞噬功能;炎症 [中图分类号]R%5, R364.5, R392. 12, R392-33 [文献标志码]A Insulin-like growth factor 1 (IGF-1) promotes phagocytic activity of mouse BV-2 microglial cells via activating PD K/AKT signaling pathway ZHAI liqian1,...
reproduction are unaffected. TheIgf1r+/-mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan.