The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of...
Here, we report that NT219, a novel IIS inhibitor, mediates a long‐lasting, highly efficient inhibition of this signaling cascade by a dual mechanism; it reduces the autophosphorylation of the IGF1 receptor and directs the insulin receptor substrates 1 and 2 (IRS 1/2) for degradation. NT...
Rivas MA, et al. Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/F...
aSchematic of the crosstalk between the insulin/IGF1 and receptor tyrosine kinase (RTK) signalling pathways. Insulin receptor (IR), IGF1 receptor (IFG1R), IGF binding proteins (IGFBPs), receptor tyrosine kinase (RTK), IGFR and IR inhibitor OSI-906 (OSI), FGF receptor tyrosine kinase inhibito...
(1 or 10 mg/kg) to a testosterone propionate-induced BPH rat model, and its effects on the prostate weight were evaluated. The effect of IQ on androgen receptor (AR) signaling was analyzed in LNCaP cells. Whether ...
reproduction are unaffected. TheIgf1r+/-mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan.
For that, the mechanisms involved in the cross-talk between the estrogen receptor and the IGF-1R were investigated. In addition, we addressed the question of whether ERα and ERβ differ in their potential to interact with the IGF-1R signaling pathway. EXPERIMENTAL PROCEDURES Cell Culture Cell ...
et al. Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. BMC Cancer 13, 235 (2013). https://doi.org/10.1186/1471-2407-13-235 Download citation Received09 October 2012 Accepted30 April 2013 Published10 May 2013 ...
Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade....
IGF-I Receptor beta Antibody detects endogenous levels of IGF-IR beta. It does not cross-react with insulin receptor. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-ter...