Editorial: Targeting the IGF-I Receptor Signaling Pathway: Implications for Human Cancer TherapyInsulin-Like Growth Factor IHumanMalignant NeoplasmsreceptorEditorial [Publication Type]胰岛素样生长因子ⅠA common molecular abnormality in human cancer is the presence of multiple autocrine loops, with one of ...
[关键词]胰岛素样生长因子l(IGF-l); B V-2小胶质细胞；吞噬功能；炎症 [中图分类号]R%5, R364.5, R392. 12, R392-33 [文献标志码]A Insulin-like growth factor 1 (IGF-1) promotes phagocytic activity of mouse BV-2 microglial cells via activating PD K/AKT signaling pathway ZHAI liqian1,...
Rivas MA, et al. Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/F...
综上所述,IQ在BPH大鼠模型中有效减小了前列腺大小,并在体外有效抑制了AR信号传导和PI3K/AKT/mTOR通路,表明其作为BPH治疗的潜力。 Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway...
Conclusion: PEMF may enhance the maturation and mineralization of rat cranial osteoblasts in vitro through IGF~1R / NO signaling pathway. 159 [ Key words] Osteoblasts / radiation effectsꎻ Skull / cytologyꎻ Electromagnetic fieldsꎻ Glycogen synthase kinase 3 / biosynthesisꎻ Receptorꎬ IGF ...
receptor (IGF1R) abolishes the E2 protection of β-cell survival. By immunoprecipitation experiments, we have demonstrated that ERα and IGF1R combine and interact with each other in the β-cells.In addition, E2 can activate two key factors of IGF1R signaling pathway - ERK and PI3K. We ...
Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade....
(1998). Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen- activated protein kinase pathway, but not the insulin... Chow,C J. - 《Journal of Biological Chemistry》 被引量: 806发表: 1998年 SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling...
The insulin-like growth factor (IGF)-Ⅱ/IGF-Ⅰreceptor (IGF-ⅠR) related signaling pathway is associated with the development and progression of hepatocellular carcinoma (HCC). Hepatic IGF-Ⅱactivation can deliver a mitogenic signal to IGF-ⅠR to increase the tumorigenic potential of liver cells...
It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1. IGF-1 signaling pathway IGF-1 ...