receptor胰岛素样生长因子Ⅰ转化生长因子β蛋白质类Insulin-like growth factor-I (IGF-I) has gained broad recognition as an important survival factor for epithelial cells in numerous tissues. The IGF-I receptor signaling pathway is deregulated in the majority of carcinomas, and such deregulation has ...
2. Iams WT, Lovly CM. Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade. Clin Cancer Res. 2015;21:4270–7. 3. Werner H, Bruchim I. The insulin-li...
Hence, the observed effects of proinflamma- tory cytokines on IGF-I–stimulated chondrocyte proliferation cannot be ascribed to reduced expression of the type 1 IGF receptor. Proinflammatory Cytokines Attenuate the IGF-I–Activated Signaling Pathways in Proliferating Cells IGF-I exerts its mitogenic ...
At target cells, the IGF-1 ligand binds IGF receptors (or insulin receptors) leading to receptor autophosphorylation and activation (3). Activated receptors mediate downstream signaling pathways (including Akt and MAPK) that regulate cell proliferation, apoptosis, dev...
IGF-1R signaling pathways. Key words Insulin-like growth factor 1; Insulin-like growth factor 1 receptor; Tumor 中图分类号:R 730.3 文献标识码:A 文章编号:1673—6567(2015)08—0200—03 DOI 编码:10.13214/jki.cjotadm.2015.08.162 ·· 200 ...
(https://shiny.crick.ac.uk/embryo_signalling/). To identify ligand and cognate receptor pairs that might suggest signalling pathways to modulate, we curated a list of ligands and receptors from all signal transduction pathways in the KEGG database, and integrated protein-protein interactions using...
The anti-proliferative actions of metformin were associated with an activation of AMP-activated protein kinase AMPKThr172 together with an inhibition of the insulin/insulin-like growth factor-I (IGF-I) receptor activation and downstream signalling mediators IRS-1 and phosphorylated Akt. Furthermore, ...
The aim of this study was to gain further insight into the interactions of the IGF-1 and the estrogen signaling pathways. For that, the mechanisms involved in the cross-talk between the estrogen receptor and the IGF-1R were investigated. In addition, we addressed the question of whether ERα...
This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated IGF-I Receptor β (D23H3) XP® Rabbit mAb #9750. MW (kDa) 95 Product Usage Information A...
(玻璃化冷冻组),另设自然交配出生子代为对照组,每组16只小鼠,检测子代小鼠出生到6月龄时各阶段体质量及6月龄成年子代鼠的空腹血糖、空腹胰岛素、糖耐量水平;取材6月龄子代小鼠肝脏组织,qRT-PCR检测生长因子受体结合蛋白10(growth factor rec...