We set out to investigate active signalling pathways in the human EPI, reasoning that as in the mouse, identifying these pathways in embryos would inform strategies for maintaining pluripotent hESCs in physiologically relevant conditions. Here we mine available datasets to identify receptor-ligand pairs ...
Using pharmacological inhibitors of the two canonical IGF-I receptor signaling pathways, we show that the phosphatidylinositol-3′-kinase (PI3K) and the Mek–Erk pathways are not required for the stimulating effect of NHS. Conclusion Our observations indicate that the stimulating effect of NHS is ...
receptor胰岛素样生长因子Ⅰ转化生长因子β蛋白质类Insulin-like growth factor-I (IGF-I) has gained broad recognition as an important survival factor for epithelial cells in numerous tissues. The IGF-I receptor signaling pathway is deregulated in the majority of carcinomas, and such deregulation has ...
reproduction are unaffected. TheIgf1r+/-mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan.
Decorin Enhances IGF-I-dependent IRS-1 Down-regulation One of the major downstream effectors of the IGF-IR signaling pathway is the docking protein insulin receptor substrate 1 (IRS-1), which upon ligand-induced recruitment to the IGF-IR regulates the activation of the PI3K and Akt pathways. ...
非专利文献2:kavran,j.m.等人,howigf-iactivatesitsreceptor.elife,2014.3; 非专利文献3:bailyes,e.m.等人,insulinreceptor/igf-ireceptorhybridsarewidelydistributedinmammaliantissues:quantificationofindividualreceptorspeciesbyselectiveimmunoprecipitationandimmunoblotting.biochemj,1997.327(pt1):第209-15页; ...
[A b s tra c t] Objective To investigate the effect of insulin-like growth factor 1(IGF-1) on the phagocytic activity of mouse BV-2 microglial cells. Methods Western blotting was performed to detect the protein levels of IGF-1 and IGF-1 receptor (IGF-1 R) in the murine brain after ...
growth factor I receptor,IGF一1R)信号通路可能在 EGFR 和K —ras 基 因均为野生型 的 NSCLC 细胞 EGFR —TKIs 获得性 耐药 中起 重要 作用 ,但 这种 耐药 机制 在 EGFR 野生型 、K —ras 突变型 NSCLC 细胞 的获得性耐药 中是 否也具普遍 性及 其可 能 的分子 学 机制 有 待进 一步 研 ...
insulin-like growth factor receptor gene expression Insulin-like growth factor-I (IGF-I) inhibits neuronal apoptosis in the developing cerebral cortex in vivo. Int J Dev Neurosci, 2007. 25(4): p. 233-41. [8]. Zhang, X., et al. , Multiple signaling pathways ...
2022 IGF-1R 通过调控 JAK/STAT 信号通路对 脓毒症大鼠作用机制的研究 胡伟,张涛,盛尚春,刘翔,丁贵梅,代琼(宜宾市第二人民医院检验科,四川宜宾 644000) 摘要:目的 探究 1 型胰岛素样生长因子受体(insulin-like growth factor 1 receptor,IGF-1R)通过调控 Janus 激酶 / 信 号转导和转录激活因子(janus kinase/...