The aim of our work was to evaluate the toxicity of rifampicin-PLLA nanoparticles against Mycobacterium bovis BCG using human macrophage THP-1 cell line. Our data demonstrate that rifampicin-PLLA is effective against M. bovis BCG in the infected macrophages. The drug is inducing the dysfunction ...
4) THP-1 macrophage THP-1巨噬细胞 1. In order to study the effects of LDL and oxLDL on expression of PCSK9 and LDLR inTHP-1 macrophages and find the relationship between them. 分别用0mg/L、10mg/L、20mg/L、30mg/L的LDL和0mg/L、10mg/L、20mg/L、30mg/L的oxLDL处理THP-1巨噬细胞,...
中文名称:THP-1人急性白血病单核巨噬细胞株说明书 中文同义词:THP-1人急性白血病单核巨噬细胞株说明书 英文名称:THP-1 Human Acute Leukemia Mononuclear Macrophage Cell Line Instructions 英文同义词:THP-1 Human Acute Leukemia Mononuclear Macrophage Cell Line Instructions ...
We subsequently deleted KEAP1 in THP-1 cells to validate the effect of KEAP1 on macrophage pro-inflammatory activation. We designed three sgRNAs to target the human KEAP1 (Supplementary Fig. 2a) with good efficiency (Supplementary Fig. 2b, c), and the KEAP1 level could be reduced in THP...
α7 nicotinic acetylcholine receptors (nAChRs) are ubiquitous in the nervous system and ensure important neurophysiological functionality for many processes. However, they are also found in cells of the immune system, where their role has been less studi
1.Expression of genes for inflammatory cytokines in human monocytic cell line THP-1 during exposure to isoflurane;目的研究异氟醚对人类单核细胞株(THP-1)细胞、白细胞介素-1β(IL-1β)、IL-8、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、IL-4和IL-10mRNA表达的影响。 3)monocyte line Raw264.7...
In support of NF-κB involvement, we observed that thrombin induced IκB phosphorylation in THP-1 macrophages, an effect that has already been reported in a murine macrophage cell line [14]. IκB may be phosphorylated by IκB kinase, which is activated in turn by a number of kinases, ...
The monocytic THP-1 human myeloid leukemia cell line [8] expresses the Fc receptor and can be induced by phorbol 12-myristate 13-acetate (PMA) to differentiate into macrophage-like morphology [9]. Upon PMA treatment the suspension culture changes and cells become adherent to glass and plastics...
NP-011 facilitates macrophage-mediated collagen uptake in lung fibrosis Elimination of accumulated collagen by immune response is another key factor in resolving fibrosis as seen in PF mouse model24. In order to assess this, THP-1 monocytes were differentiated into macrophages by PMA treatment (Fig...
a, Schematic of human germ cell development. Differentiation stages, key markers and stages covered by this study (yellow) are shown.b, Summary of the acronyms used in this study.c, Flow cytometric analysis of the expression of AG and DT or VT during BMP-driven M1-AGDTor F1-AGVThPGCLC ...