Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor...
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Beyond that, we recommend the development of space-based short-radius centrifuges and variable-gravity research facilities to investigate some questions that cannot be answered on the ground and to validate human responses to artificial gravity prescriptions in space. Whether used in the near-term to...
The extraction method of interface protein refers to previous study and has been slightly adjusted[4]. A 30 mL simulated MFG emulsion was poured into a centrifuge tube and centrifuged at 10,000g(4 °C, 30 min). The lower serological phase was removed, finally collected the upper cream phase...
such that either non-viable fetuses are produced, or limited life-span animals are produced. In addition, the effects of multiple gene knockouts or transgenes are extremely difficult to simulate in such systems, due to the complex temporal, gene regulatory and interaction effects in such systems....
Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment o
As opposed to earlier studies which often used animal models and animal cell lines, respectively, we employed human cell lines in order to better transfer the results to patients. Furthermore, the applied stimulation was modeled to simulate the clinical settings. We stimulated with short impulses ...
Long-term space travel simulation experiments enabled to discover different aspects of human metabolism such as the complexity of NaCl salt balance. Detailed proteomics data were collected during the Mars105 isolation experiment enabling a deeper insight
Transcriptome deconvolution aims to estimate the cellular composition of an RNA sample from its gene expression data, which in turn can be used to correct for composition differences across samples. The human brain is unique in its transcriptomic diversi
HPSC-derived PPs are dissociated and re-aggregated into PP 3D clusters by centrifuge and incubation in a V-shaped-bottom microplate and then transferred to the air–liquid interface. The PPs in 3D clusters mainly differentiate into β-cells after they are successively treated by PP-10C, EP-8C...