Having confirmed a series of pertinent observations, we then attempted to use the overlap metric Δ to identify new trends in this chemical space. The most striking observation concerns the heterogeneity of the PPI targets. Indeed, a rapid overlook of all of the individual PPI targets from both...
Introduction: The N-terminus of a protein can encode several protein features, including its half-live and its localization. As the proteomics field remains dominated by bottom-up approaches and as N-terminal peptides only account for a fraction of all analyzable peptides, there is a need for...
“Mass spectrometry has long been a powerful technique to identify post-translational modifications and will continue to be one of the primary methods,” says John Yates, a faculty member in cell biology at the Scripps Research Institute. According to Yates, “recent improvements in mass ...
Protein coding features can emerge de novo in non coding transcripts, resulting in emergence of new protein coding genes. Studies across many species show that a large fraction of evolutionarily novel non-coding RNAs have an antisense overlap with protei
Macrophages are the first to sense an intruder in the body, so it is their responsibility to accurately identify the intruder and instruct the rest of the immune system's response. To ensure that the correct response is mounted, macrophages require very specific internal signaling. ...
Let's focus on immunity first, which is the ability of the immune system to fight against pathogens. If immunity is like an army, while the virus is the enemy force. When the enemy (germ) wants to invade us, the ...
Newer functional foundation models (such as ProteinBERT) go beyond the structure to estimate these functional properties of interest directly.5 Once a set of possible candidates has been identified, AI and ML can be used to facilitate mass in silico screening of thousands of CAR constructs...
[93]. NGS has become a crucial method in the analysis of vascular tissue, allowing for the identification of several genes involved in xylem and phloem development, cell wall biosynthesis, cell division, and protein synthesis/turnover [12]. Notably, NGS has helped identify NAC-domain-containing...
These are biologically important questions because the answer to the first two questions could impact our understanding of how protein homeostasis is maintained in cells. The answer to the final question would help to explain how synonymous mutations can have long term impacts on protein structure and...
We discuss known 5′ UTR RNA structures and how new structure probing technologies coupled with prospective validation, particularly compensatory mutagenesis, are likely to identify classes of structured RNA elements that shape post-transcriptional control of gene expression and the development of ...