How protein structure is organized and assembled at the sub-nanometer scale is of great current interest. Specifically, the discovery of stable substructures and supersecondary structures has inspired research into their potential use in rationally engineered proteins with tailor-made properties. Here, ...
The Composition of two functions is often difficult to be understood. We will be using an example problem involving two functions to demonstrate how to find the composition of those two functions in an easy way. Step 1 We will be solving (F?G)(x), when f(x)=3/(x-2) and g(x)=2...
We also discuss the challenges and ongoing efforts in using artificial intelligence-based protein structure prediction methods to discover metamorphic proteins and predict their corresponding three-dimensional structures. 展开 关键词: Metamorphic proteins Fold-switch Protein biophysics Coevolution Protein ...
The very first of the thousand steps, if you want to find something new, is to learn to live with uncertainty, and to learn to accept failure as the norm, because looking for the unknown is like being a trapeze...
这里我们给大家推送的是Karl Barry Sharpless教授2008年11月在中国天津大学Honeywell Nobel Lecture上给过的一个异常而且极为精彩的演讲。报告的题目是:“How to find something new”(如何发现新事物),Barry一生做过很多重要的演讲,但这个演讲可以说是其中最特殊的一次!(不论形式还是内容) ...
How Much Protein Do You Need? Intake Guidelines Proteins are the basic building blocks of the human body. They are made up ofamino acidsand are needed for the structure and function of muscles, blood, skin, hair, nails, and internal organs. Next to water, protein is the most abundant sub...
“The most reliable approach to localize a post-translational modification in the primary structure of a protein or peptide is the recording of tandem MS spectra,” says Albert Sickmann, group leader of the Protein Mass Spectrometry & Functional Proteomics Group at the University of Würzburg. “...
Single-nucleotide-resolution chemical RNA structure probing is emerging to explore the folding state of the transcriptome in living cells; the resulting models for how 5′ UTR structures impact translation should be validated by compensatory mutagenesis.Abstract...
Rubin's team used x-ray crystallography to figure out the three-dimensional structure of the retinoblastoma protein with the phosphatase enzyme bound to it. To their surprise, they found that when the phosphatase attaches to the protein to close the gate, it binds to the same site known to ...
Cells through different mechanisms, gain the ability to invade and destroy surrounding normal anatomy which makes possible radical surgery inadequate as a treatment modality. Glioblastoma is notorious for gross and microscopic invasiveness. Calmodulin, a multifunctional Ca2+-binding protein, is thought to ...