Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo ...
Pseudomonas aeruginosa,CP-CRPA), makes special proteins that prevent most available antibiotics from working. That includes carbapenems, powerful antibiotics which are prescribed when no other treatment has worked. CP-CRPA is also able to share its genetic code with other bacteria, kind of like shar...
Having confirmed a series of pertinent observations, we then attempted to use the overlap metric Δ to identify new trends in this chemical space. The most striking observation concerns the heterogeneity of the PPI targets. Indeed, a rapid overlook of all of the individual PPI targets from both...
Our model can thus can be used to identify the cases where the null hypothesis does not hold true, which can be further studied to test different alternative hypotheses. We believe our work opens up interesting questions and avenues for future research. For example, the cellular functions and ...
Other complicating factors, says Sickmann of the University of Würzburg, include “varying amounts of isoforms in between proteins or even single glycosylation sites,” as well as transient modifications of the glycan moieties. Marshall elaborates on this, explaining that one can identify ...
Macrophages are the first to sense an intruder in the body, so it is their responsibility to accurately identify the intruder and instruct the rest of the immune system's response. To ensure that the correct response is mounted, macrophages require very specific internal signaling. ...
Engaging communication experts in a Delphi process to identify patient behaviors that could enhance communication in medical encounters p pBackground/p pThe communication literature currently focuses primarily on improving physicians verbal and non-verbal behaviors during the medical interv... JK Rao,LA ...
How can protein catabolism help identify microbes? Explain how protein is digested in the body. Describe how carbohydrates, proteins, and fats are used to meet the energy needs of the body. Describe how the chemical structure of proteins differs...
proteins, likemonoclonal antibodiesand cell signaling proteins. Unlike most chemically-derived small-molecule drugs, biological products are generally derived from a living organism, such as humans, animals, microorganisms or yeast. Clinically, they are used to treat patients with cancer, kidney diseases...
Imagine that you have just invested a substantial amount of time and money in a shotgun proteomics experiment designed to identify proteins involved in a particular biological process. The experiment successfully identifies most of the proteins that you already know to be involved in the process and...