HLA-A2.1 transgenic mice were immunized with a DNA vaccine optimized for NS3 specific epitope presentation and induced CD8+ T cell reactivity was screened using 42 algorithm-predicted peptides as well as a library of 78 overlapping 15-mer peptides spanning the whole protein. Three epitopes ...
Protein expression analysis Strain specific B2M and HLA expression analysis in homozygous B-HLA-A2.1 mice by flow cytometry. Splenocytes from both wild-type C57BL/6 (+/+) and homozygous B-HLA-A2.1 mice (H/H) were analyzed by flow cytomet
HLA-A11, HLA-A24 and HLA-b40 transgenic mice. Of note, HLA-A2 restricted, HPV18 E7 peptide (aa7-15)- and HPV18 E6 peptide (aa97-105)-specific epitopes are endogenously processed by HPV18 positive Hela-AAD (HLA-A*0201/Dd) cells. Finally, we found that injection of DNA plasmids ...
NSG-HLA-A2/HHD 突变小鼠具有免疫缺陷并表达人I 类HLA重链和轻链。此品系可作为人造血细胞移植的宿主,当植入人造血干细胞时,支持人 T 细胞的成熟。 如需订购植入CD34+ 或 PBMC 的此模型,请访问“人源化小鼠”页面。 https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/humanized-mice 品系亮点...
Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic–T-lymphocyte responses in HLA-A2.1 transgenic mice Clin Diagn Lab Immunol, 12 (2005), pp. 1223-1230 View in ScopusGoogle Scholar [41] GG Vaday, O Lider Extracellular matrix moieties, cytokines, and...
HLA-A2 transgenic mice immunised with MVA expressing Gpn developed HLA-A2-restricted responses against two CTL epitopes known to be immunogenic in HIV infected individuals. In addition, the candidate vaccine specifically triggers the in vitro expansion of human HIV-1-specific CD8+ T cells. ...
Abstract 2504: A therapeutic Her2-Neu cancer vaccine alone or in combination with anti-Her2 mAb inhibits tumor growth in HLA-A2 transgenic mice Her2/neu is a validated target in cancer, as various antibodies (Abs) against this antigen have demonstrated their clinical efficacy in patients presenting...
FIG. 31 shows the results of treatment of human BV173 in NSG mice using antibodies of the invention. FIG. 32 shows that at later time points, mice treated with WT1 antibody only began to relapse, while antibody with effectors cured 2 of 5 mice. ...
Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Dengue is a mosquito-borne viral disease of humans, and animal models that recapitulate human immune responses or dengue pathogenesis are needed to underst... S Jaiswal,P Pazoles,M Woda,.....
An anti-B6.A2 T-cell line from mice that underwent transplantation made proliferative responses to B6.A2 splenocytes but did not recognize HLA-A2 on human cells or transfected allogeneic mouse cells. The indirect, self-H-2-restricted recognition of HLA-A2 implied by this was confirmed...