Protein expression analysis Strain specific B2M and HLA expression analysis in homozygous B-HLA-A2.1 mice by flow cytometry. Splenocytes from both wild-type C57BL/6 (+/+) and homozygous B-HLA-A2.1 mice (H/H) were analyzed by flow cytomet
Mouse B2M was detectable in splenocytes of wild type mice but not in homozygous B-HLA-A2.1 mice. The percentage of T cells, B cells, CD4+ T cells, and CD8+ T cells within the spleens of homozygous B-HLA-A2.1 mice were similar to those in the wild type mice, demonstrating that...
HLA-F Yes Yes ? ? LIR1, LIR2 Bladder, liver, placenta, lymphoblasts HLA-G Yes Yes Pep8-9aa Yes LIRs Placenta, thymus, macrophages, dendritic cells, alloreactive T cells a Qa1 is the functional equivalent of HLA-E in mice.? implies the cargo and TCR recognition is unknown. Although...
除了上述关于LDHC表达水平的研究外,Thomas等人还报道了LDHC来源的多肽诱导的T细胞对内源性LDHC表达的乳腺癌细胞株HLA-A*0201具有杀伤活性。Naik和Decock报道,下调乳腺癌细胞中LDHC的表达增加了DNA损伤和细胞凋亡。这些研究高度表明,与LDHA类...
位于MHC的I类区的MIC(MHC class I chain related)基因家族包括两个表达基因MICA和MICB,以及五个假基因(MICC、MICD、MICE、MICF和MICG)(图1)。 图1. 人类主要组织相容性复合体(MHC)图谱。 MIC分子与经典的人类白细胞抗原(HLA)分子具有同源性,但是MICA和MICB都是异常大的基...
Abstract It is now over 50 years since Gorer’s discovery of H-2 (1,2) and 30 years since Dausset’s description of the first HLA specificity — HLA-A2 (3). Just prior to this conference, that same molecule provided the first three-dimensional structure of a transplantation antigen (4...
Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Dengue is a mosquito-borne viral disease of humans, and animal models that recapitulate human immune responses or dengue pathogenesis are needed to underst... S Jaiswal,P Pazoles,M Woda,.....
To determine the specificity of the T cell response to the HCV VLPs HLA-A2kb transgenic mice (HHD) were vaccinated with HCV VLPs or PBS subcutaneously as above or intranasally with 50 µl (25nmol) of the lipopeptide (OT2 Pam2CysGIL) on days 0 and 9. This vaccine contains the ...
了人类第一个白细胞抗原,即Mac抗原,也就是后来被称为HLA-A2的抗原,首 次证实了人类白细胞膜上的抗原具有型的特异性阳～。自从Mac抗原发现以后, HLA系统的的研究得到了迅猛的发展,新的HLA抗原不断被发现,人们很快认识 到HLA系统是一个远比人类红细胞抗原系统复杂的系统。而Mac抗原的发现不仅 是HLA系统研究中的...
保质期:1 year 适应物种:Enoblituzumab 用途:For Research Use Only. 纯度:95% 产地:France 品牌:AntibodySystem 包装规格:96 assays 标记物:Unconjugate 样本:Plasma, Serum 检测方法:Elisa 应用:Elisa 检测限:0.156 ug /ml 货号:KDJ04001 是否进口:否 ...