HLA-A2.1 transgenic mice combined with immunologically reconstituted tumour-bearing mice were used to examine the antitumour effect and safety of epitope vaccines. Results We identified novel HLA-A2.1-restricted extracellular matrix protein 1(ECM1)-derived immunodominant epitopes in which LA induced a ...
"Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element." J Immunol 142(4): 1366-1371. 3.Vitiello, A., D. Marchesini, J. Furze, L. A. Sherman and R. W. Chesnut (1991). "Analysis of the HLA-...
The splenocytes of the immunized mice were fused with cells from the murine myeloma NS-1. In an initial screening, supernatants of growing cultures were tested for their binding capacity to the immunizing P815/A1 + cells as well as to P815/A2 + cells. Three out of 756 hybrids ...
The HLA-A2 molecule also has its own peptide in the signal sequence that does not require cytosolic processing or TAP transport33,34 and, thus, is less affected by the transgenic hTAP-LMP genes. Increased CTL responses against HLA-A11-restricted epitopes in the HLA-A11/hTAP-LMP mice. ...
Abstract: The mechanistic basis by which the H2g7 major histocompatibility complex (MHC) provides the primary risk factor for the development of T cell–mediated autoimmune type 1 diabetes (T1D) in non-obese diabetic (NOD) mice involves contributions not only from the unusual Ag7 class II ...
Khanna R, Burrows SR, Nicholls J, Poulsen LM: Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes. Eur J ...
本团队前期 建立了HLA-A2转基因小鼠筛选NY-ESO-1特异性TCR 的体系, 所筛选的TCR能够特异性识别NY-ESO-1表位, 制备的TCR-T细胞能够对携带NY-ESO-1的靶细胞产生 T细胞免疫应答[29]. 本研究通过免疫HLA-A*11:01转基 因小鼠, 对WT1抗原HLA-A11限制性T细胞表位进行了 鉴定, 并成功鉴定出一条HLA-A*11:01...
We have generated a panel of transgenic mice expressing HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02, or -C*07:01 as chimeric monochain mo... R Boucherma,H Kridane-Miledi,R Bouziat,... - 《Journal of Immunology》 被引量: 41发表: 2013年 HLA-A, ...
Identification of HLA-A2 restricted epitopes of glypican-3 and induction of CTL responses in HLA-A2 transgenic mice Xiaoxiao Jin Xiaotao Liu Chuanlai Shen Cancer Immunology, Immunotherapy (2022) Diagnostic utility of p501s (prostein) in comparison to prostate specific antigen (PSA) for the det...
HLA A2 (A2) transgenic mice are currently being used to compare different vaccination protocols. However, the monitoring of A2 restricted CTL in A2 transgenic mice have been hampered by poor staining efficiency of mouse CTL by A2 tetramers. We demonstrate here that chimeric A2 tetramers containin...