HLA-A2 and -A24-restricted glypican-3-derived peptide vaccine induces specific CTLs: preclinical study using mice. Int. J. Oncol. 32, 985-990.Motomura Y, Ikuta Y, Kuronuma T, et al. HLA-A2 and A24- restricted glypican-3-derived peptide vaccine induces specific CTLs: preclinical study ...
2007: Hepatitis B virus core antigen epitopes presented by HLA-A2 single-chain trimers induce functional epitope-specific CD8+ T-cell responses in HLA-A2.1/Kb transgenic mice Immunology 121(1): 105-112 Kinfe, H.; Sendo, E.G.; Gebremedhin, K.B. 2021: Prevalence of Hepatitis B Virus ...
In vivo activity of CUE-102 molecules was assessed in HLA transgenic mice. CUE-102 Immuno-STATs presenting HLA-A*02 or A*24 specificities demonstrated selective binding and TCR triggering of WT1-specific CD8 T cells. Signaling, cell-based assays and cytokine release studies confirmed significant ...
We used active immunization with recombinant Yo protein of four strains of mice bearing different MHC molecules: BALB/c ( H-2d ), C3H ( H-2k ), C57BL/6 ( H-2b ), SJL/J ( H-2s ). All the strains produced high anti-Yo antibody titer but none developed cerebellar ataxia or showed...
The spleen parasite burden of each group demonstrated that the CaNA2 vaccine had a certain immune protective effect on visceral leishmaniasis in BALB/c mice, and the amastigote reduction rate reached 76%. Preliminary safety tests confirmed the safety of the vaccine. Our work demonstrates that the...
(iv), in HLA-A * 2402 transgenic mice, and selection of those that are immunogenic; (vi) for each epitope selected in step (v), testing to determine if the LTC generated against the optimized epitope also recognize its similar natural epitope, and selecting those for which the test is ...
We previouslyrnidentified SOX6 as a human glioma antigen and demonstrated that vaccination with SOX6 DNA induced cytotoxic Trnlymphocytes (CTLs) specific for glioma, thereby exerting therapeutic antitumor responses in glioma-bearing mice. In thisrnstudy, we attempted to identify SOX6-derived peptides...
Moreover, we demonstrated the effectiveness of adoptive cell therapy with WT#213 CAR against the WT1 expressing HLA-A24:02 positive human leukemia cells, utilizing NOG immunodeficient mice. To evaluate the safety of the WT#213 CAR, we predicted the potential property of WT#213 CAR to cross-...
Identification of DENV3 HLA class I (A02, B07 and A24) T-cell epitopes using HLA transgenic mice, epitope prediction and binding assays.Eduardo J. M. NascimentoRobbie B. MailliardAsif M. KhanJohn SidneyAlessandro SetteNicole GuzmanMichael Paulait...