Splenocytes from both wild-type C57BL/6 (+/+) and homozygous B-HLA-A2.1 mice (H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry. Mouse B2M and H-2Db were detectable in the wild-type C57BL/6 mice. Human B2M and HLA-A2 were only detectable in the ...
HLA-A2.1 transgenic mice combined with immunologically reconstituted tumour-bearing mice were used to examine the antitumour effect and safety of epitope vaccines. Results We identified novel HLA-A2.1-restricted extracellular matrix protein 1(ECM1)-derived immunodominant epitopes in which LA induced a ...
通用名称:NSG-HLA-A2/HHD NSG-HLA-A2/HHD 突变小鼠具有免疫缺陷并表达人I 类HLA重链和轻链。此品系可作为人造血细胞移植的宿主,当植入人造血干细胞时,支持人 T 细胞的成熟。 如需订购植入CD34+ 或 PBMC 的此模型,请访问“人源化小鼠”页面。 https://www.jax.org/jax-mice-and-services/in-vivo-pharmacolo...
Ex-vivo evaluation of the specific response against six peptides (5 µg/ml/peptide) in HLA A2/DR1 mice. 来自 figshare.com 喜欢 0 阅读量: 29 作者:N Seyed,T Taheri,C Vauchy,M Dosset,Y Godet,A Eslamifar,I Sharifi,O Adotevi,C Borg,P Simon Rohrlich ...
Mata M, Travers PJ, Liu Q, Frankel FR, Paterson Y: The MHC class I-restricted immune response to HIV-gag in BALB/c mice selects a single epitope that does not have a predictable MHC-binding motif and binds to Kd through interactions between a glutamine at P3 and pocket D. J Immunol...
免疫HLA-A*11:01转基因小鼠流程; (b) ELI- SPOT实验检测WT1414-423多肽引起小鼠脾细胞分泌IFN-γ反应图; (c) 流式检测Mus-2小鼠脾细胞CD3+/CD8+/四聚体+细胞比例并进行单细胞 分选 Figure 1 (Color online) Single-cell isolation of WT1414-423-specific T cells from HLA-A*11:01 transgenic mice....
Das erste HLA Merkmal (HLA = human /eukocyte antigen, locus A) wurde 1958 von Dausset [20] beschrieben, wofür er 1980 den Medizin-Nobelpreis erhielt. Dieses Antigen, das vorerst als „Mac“ bezeichnet wurde und das dem heutigen HLA-A2 entspricht,...
12 1 ously.The size of the mass at the injection site was measured.In 5 groups of the mice,the average diameters of the tumor were respec— ti vely 15 .11 ±2 .4 3 mm ,13 .70 ±2 .97 mm ,13 .0 5 ±1 .77 mm,7 .4 6 ±2 .6 1 mm and 9 .0 5 ±2 .18 mm ;Ep ...
淋巴细胞,候选肽能否将它激活.而标准的<'51>Cr释放实验则检测激活的特异性CTL能否有效杀伤NY-BR-1和HLA-A2均表达阳性的乳腺癌细胞系SK-BR-3,证明候选肽是不是肿瘤细胞天然呈递的HLA-BR-A2限制性的CTL表位.综上所述,候选肽MLLQQNVDV<,(167~175)>和NMWLQQQLV<,(1274~1282)>是NY-BR-1的HLA-A2限制性的...
Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Dengue is a mosquito-borne viral disease of humans, and animal models that recapitulate human immune responses or dengue pathogenesis are needed to underst... S Jaiswal,P Pazoles,M Woda,.....