Splenocytes from both wild-type C57BL/6 (+/+) and homozygous B-HLA-A2.1 mice (H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry. Mouse B2M and H-2Db were detectable in the wild-type C57BL/6 mice. Human B2M and HLA-A2 were only detectable in the ...
A spontaneous HPV16 E6/E7-expressing oral tumor model in human HLA-A2 (AAD) transgenic mice will be important for the development of therapeutic HPV vaccines for the control of HPV-associated head and neck cancers.In the current studies, we characterized the HLA-A2 restricted HPV16 E7-specific...
Das erste HLA Merkmal (HLA = human /eukocyte antigen, locus A) wurde 1958 von Dausset [20] beschrieben, wofür er 1980 den Medizin-Nobelpreis erhielt. Dieses Antigen, das vorerst als „Mac“ bezeichnet wurde und das dem heutigen HLA-A2 entspricht,...
通用名称:NSG-HLA-A2/HHD NSG-HLA-A2/HHD 突变小鼠具有免疫缺陷并表达人I 类HLA重链和轻链。此品系可作为人造血细胞移植的宿主,当植入人造血干细胞时,支持人 T 细胞的成熟。 如需订购植入CD34+ 或 PBMC 的此模型,请访问“人源化小鼠”页面。 https://www.jax.org/jax-mice-and-services/in-vivo-pharmacolo...
Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic–T-lymphocyte responses in HLA-A2.1 transgenic mice Clin Diagn Lab Immunol, 12 (2005), pp. 1223-1230 View in ScopusGoogle Scholar [41] GG Vaday, O Lider Extracellular matrix moieties, cytokines, and...
Qa1 is the functional equivalent of HLA-E in mice.? implies the cargo and TCR recognition is unknown. Although HLA-E selectively presents peptides from the leader sequences of HLA class I molecules, HLA-E also binds other noncanonical peptides (Table 2). These peptides derive from normal,...
来源于SART-1的HLA-A2限制性肿瘤抗原肽及其功能上具有同等特性的衍生物;应用肿瘤抗原肽等的肿瘤预防剂或诊断剂;与肿瘤抗原肽相关的重组DNA,重组肽和抗体及其应用;提呈肿瘤抗原肽的抗原提呈细胞及其应用;肿瘤抗原肽特异的细胞毒性T细胞及其应用.主权项: 权利要求书\r\r\r\r\n1.肿瘤抗原肽或其功能上具有同等特性的...
Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the TE ERV-K is frequently express
H2-deleted, HLA-A2, or HLA-B7 transgenic mice were used to identify new human cytomegalovirus (HCMV)-derived major histocompatibility complex class I-restr... Pierre,S,Rohrlich,... - 《Human Immunology》 被引量: 49发表: 2004年 Preparation and Characterization of HLA-A * 0201 Monomer and...
HLA-A2 transgenic mice immunised with MVA expressing Gpn developed HLA-A2-restricted responses against two CTL epitopes known to be immunogenic in HIV infected individuals. In addition, the candidate vaccine specifically triggers the in vitro expansion of human HIV-1-specific CD8+ T cells. ...