Genomic high-throughput technologies (GHTT) such as next-generation sequencing represent a fast and cost-effective tool toward a more comprehensive understanding of the molecular background of complex diseases. However, technological advances contrast with insufficient application in clinical practice. Thus,...
Principal component analysis (PCA) has gained popularity as a method for the analysis of high-dimensional genomic data. However, it is often difficult to interpret the results because the principal components are linear combinations of all variables, and the coefficients (loadings) are typically non...
A Perspective on the open-source and open-development software project Bioconductor provides an overview for prospective users and developers dealing with high-throughput data in genomics and molecular biology. Bioconductor is an open-source, open-develo
This thesis deals with integrative analysis of two (different) multi-dimensional data types in the context of genomic cancer research. Firstly, simultaneous clustering of two high-throughput data sets optimizing the output of iCluster program. Secondly, developing a novel the Gene Set Score (GSS) ...
NCBI GEO: archive for high-throughput functional genomic data The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest public repository for high-throughput gene exp... B Tanya,DB Troup,SE Wilhite,... - 《Nucleic Acids Research》 被引量: 19...
Bioinformatics Toolbox™ provides algorithms to support common analysis workflows for Next-Generation Sequencing (NGS) data, such as filtering and trimming reads, mapping reads to references, counting the number of reads mapped to genomic features, and performing statistical analyses. Highlighted Topics...
Chromosomal localization and gene structure were analyzed with reference to the high-throughput genomic sequence database http://www.ncbi.nlm.nih.gov. Expression profiles were searched for using GNF SymAtlas v1.0.4 http://symatlas.gnf.org/SymAtlas/. The putative cleavage site of signal peptides ...
The Jackson Laboratory for Genomic Medicine, Farmington, 06032, CT, USA Akintunde Emiola & Julia Oh Contributions A.E. and J.O.: Conception, experimental design, software development, data analysis, and manuscript writing. Corresponding author Correspondence to Julia Oh. Ethics declarations Competing...
Given recent advances in the generation of high-throughput data such as whole-genome genetic variation and transcriptome expression, it is critical to come up with novel methods to integrate these heterogeneous datasets and to assess the significance of identified phenotype-genotype relationships. Recent...
This thesis focuses on the development of such computational tools and methods for the management and analysis of high-throughput data generated from two popular platforms, Microarrays and Next Generation Sequencing.The work comprises of two separate parts differing in genomic platforms in question. ...