Conclusion: Black children with sickle cell trait or hemoglobin C trait have an increased risk of invasive pneumococcal disease. 展开 关键词: Humans Streptococcus pneumoniae Pneumococcal Infections Sickle Cell Trait Hemoglobin C Population Surveillance Child, Preschool Infant, Newborn Infant Risk Factors ...
Patients with sickle cell trait may experience mild if any, symptoms at all. In sickle cell disease, symptoms are more significant, especially in episodes of acute crisis. These symptoms can include: Generalized body aches and pain Chest pain Bone pain Shortness of breath Ulceration of the ...
The rarity of hemoglobin (Hb) H disease in combination with sickle trait may be due in part to the absence of actual Hb H in individuals who, nonetheless, have inherited the deletion of three alpha-globin genes. We describe here a boy with persistent microcytic, hypochromic anemia despite ade...
Gross hematuria in sickle cell trait and sickle cell hemoglobin-C disease. Am J Med 1955;19:773-82.CHAPMAN, A. Z. and P. S. REEDER, I. FRIEDMAN and L. A. BAKER. Gross Hematuria in Sickle Cell Trait and Sickle Cell Hemoglobin C. Disease. Am. J. Med., 19: 733-781, 1955....
Patients with sickle cell trait may experience mild if any, symptoms at all. In sickle cell disease, symptoms are more significant, especially in episodes of acute crisis. These symptoms can include: Generalized body aches and pain Chest pain Bone pain Shortness of breath Ulceration of the ...
Because sickle cell anemia and sickle cell trait are so much more common in African Americans than in other racial and ethnic groups in our population, racism and racial discrimination have been part of the American experience with this genetic disorder. In the late 1950s, when it became e...
77. Some of these factors, including malaria-induced and iron deficiency anemia, hemoglobinopathies such as sickle cell disease and thalassemia, and antiretroviral therapy, are more prevalent in parts of Asia and Africa78,79,80, and may have shifted the population distribution of HbA1c or ...
Accurate quantitation of HbA2by HPLC or microcolumn chromatography is essential for the diagnosis of β thalassaemia trait, in which the HbA2is elevated, typically >3.5%. Carriers of ‘normal A2’ or ‘silent’ β thalassaemia due to mild β gene defects or co-inheritance of a δ gene mutat...
In cases of hereditary persistence of fetal hemoglobin, genetic determinants that affect transcription include point mutations or large deletions within the β-globin locus5 as well as quantitative trait loci on chromosomes 2p15,6 6q23,7 and 8q11.8 It is assumed that the capacity to induce HbF...
(fetal hemoglobin) and HbA2, both of which can be elevated in thalassemia, a relatively common condition characterized by an imbalance of hemoglobin alpha and beta subunits. Beta thalassemias can also occur in the presence of HbE and HbS, and the combined sickle/beta thalassemia trait occurs ...