In patients with the β-thalassemia trait, the Mentzer index is usually less than 13; in patients with iron deficiency, it is usually greater than 13. 93 In a child with suspected iron deficiency anemia, is a therapeutic trial with iron an acceptable diagnostic approach? Yes. If an infant ...
Patients who are heterozygous (one normal β-globin gene and one mutant β-globin) have more moderate anemia and produce enough β-globin chains to obviate the need for ongoing transfusions—referred to as β-thalassemia trait, or β-thalassemia minor. In patients with thalassemia, the issue...
The study showed that CHr has a strong correlation with hemoglobin, MCV, and MCH, meaning that CHr combined with these conventional parameters appears to be available and reliable in identifying IDA [19]. Our study shows that the best threshold for CHr in diagnosing IDA is 27.2 pg. This ...
Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia. Br. J. Haematol. 2006, 133, 675–682. [Google Scholar] [CrossRef] Lai, M.I.; Garner, C.; Jiang, J.; Silver, N.; Best, S.; Menzel, S.; Thein, S.L. A twins ...
Figure 1.Chromatogram of HbA1c determination on CE of Hb variants’ samples. (a) A2A: Normal; (b) Hb CS trait; (c) β-thalassemia trait; (d) Heterozygous HbE; (e) Homozygous HbE; (f) CSEA Bart’s. As shown inTable 1, comparing the levels of HbA1c and FPG among the groups of...